Document Detail

Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats.
MedLine Citation:
PMID:  18306011     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Although the delta-opioid agonist SNC80 has been shown to attenuate hind-limb motor function and gray matter injury in normothermic rats subjected to spinal cord ischemia (SCI), its effects on white matter injury remain undetermined. In the present study, we investigated whether SNC80 could attenuate white matter injury in normothermic and mildly hypothermic rats. METHODS: Forty rats were randomly allocated to one of following five groups: vehicle or SNC80 with 10 min of SCI at 38 degrees C (V-38-10m or SNC-38-10m, respectively), vehicle or SNC80 with 22 min of SCI at 35 degrees C (V-35-22m or SNC-35-22m, respectively), or sham. SNC80 or vehicle was intrathecally administered 15 min before SCI. Forty-eight hours after reperfusion, the white matter injury was evaluated by the extent of vacuolation. RESULTS: The percent area of vacuolation in the ventral white matter was significantly lower in the SNC-38-10m and SNC-35-22m groups compared with that in the V-38-10m and V-35-22m groups, respectively (P < 0.05). CONCLUSION: The results indicate that intrathecal treatment with the delta-opioid agonist SNC80 can attenuate the ventral white matter injury following SCI in rats under normothermic and mildly hypothermic conditions.
Toshinori Horiuchi; Masahiko Kawaguchi; Naoko Kurita; Satoki Inoue; Takanori Sakamoto; Mitsutoshi Nakamura; Noboru Konishi; Hitoshi Furuya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-27
Journal Detail:
Title:  Journal of anesthesia     Volume:  22     ISSN:  0913-8668     ISO Abbreviation:  J Anesth     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Department of Anesthesiology, Nara Medical University, Kashihara, Nara, Japan.
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MeSH Terms
Benzamides / pharmacology*
Body Temperature / physiology
Disease Models, Animal
Hindlimb / physiology
Hypothermia, Induced*
Injections, Spinal
Motor Activity / drug effects,  physiology
Neurons / drug effects*,  pathology
Piperazines / pharmacology*
Random Allocation
Rats, Sprague-Dawley
Receptors, Opioid, delta / agonists*
Single-Blind Method
Spinal Cord Ischemia / etiology,  pathology,  prevention & control*
Treatment Outcome
Reg. No./Substance:
0/Benzamides; 0/Piperazines; 0/Receptors, Opioid, delta; 156727-74-1/4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide

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