Document Detail


Effects of deletion variant of hepatocyte growth factor on reduced-size liver transplantation in rats.
MedLine Citation:
PMID:  10428264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The deletion variant of hepatocyte growth factor (dHGF) exerts mitogenic and antifibrotic effects. The purpose of this study was to evaluate the effect of dHGF on rats that had undergone syngeneic or allogeneic reduced-size (60%) orthotopic liver transplantation (ROLT). METHODS: Starting immediately after the syngeneic (Lewis to Lewis) and allogeneic (Lewis to Brown Norway) ROLT, 500 microg/kg dHGF was administered i.v. twice a day until the day the rats were killed. Its effect on hepatic graft weight, regeneration, and biochemical parameters was evaluated. RESULTS: dHGF promoted restoration of the liver volume and liver regeneration as well as protein synthesis in the rats that underwent syngeneic ROLT. In the rats that underwent allogeneic ROLT, dHGF reduced the level of serum cytosolic enzymes related to acute cellular rejection, but a significant improvement in liver regeneration and protein synthesis was not seen. When tacrolimus was administered to prevent rejection of the allogeneic grafts, the beneficial effect of dHGF was apparent, and was as beneficial as in syngeneic ROLT. CONCLUSIONS: Administering dHGF after liver transplantation augments the regeneration and functional recovery of partial liver grafts and reduces hepatocyte injury in acute cellular rejection.
Authors:
H Uchiyama; K Yanaga; T Nishizaki; Y Soejima; T Yoshizumi; K Sugimachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  68     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Affiliation:
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoko, Japan. huchi@surg2.med.kyushu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival / physiology
Cytosol / enzymology
Genetic Variation
Graft Rejection / pathology
Graft Survival / drug effects
Hepatocyte Growth Factor / genetics*
Liver Regeneration
Liver Transplantation / immunology*
Male
Protein Biosynthesis
Rats
Rats, Inbred BN
Rats, Inbred Lew
Sequence Deletion / genetics
Chemical
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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