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Effects of delayed cord clamping on neurodevelopment and infection at four months of age: a randomised trial.
MedLine Citation:
PMID:  23336628     Owner:  NLM     Status:  Publisher    
AIM: To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G and symptoms of infection during the first four months of life. METHODS: Full-term infants (n=382) were randomised to delayed (≥ 180 seconds) or early cord clamping (≤ 10 seconds). The Ages and Stages Questionnaire was used to assess neurodevelopment at four months. Immunoglobulin G was measured at birth, two to three days and four months. Parents recorded any symptoms indicating infection during the first four months of life. RESULTS: The total scores from the Ages and Stages Questionnaire did not differ between groups. However, the delayed cord clamping group had a higher mean (SD) score in the problem solving domain (55.3 (7.2) versus 53.5 (8.2), p=0.03) at four months and a lower mean (SD) score in the personal-social domain (49.5 (9.3) versus 51.8 (8.1), p=0.01). The immunoglobulin G level was higher in the delayed cord clamping group at two to three days (11.7 g/L versus 11.0 g/L, p=0.004), but did not differ between the groups at four months. Symptoms of infection were comparable between the groups. CONCLUSION: Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to four months of age, but may have an impact on specific neurodevelopmental domains. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Ola Andersson; Magnus Domellöf; Dan Andersson; Lena Hellström-Westas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Department of Paediatrics, Hospital of Halland, Halmstad, Sweden; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
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