| Effects of delayed cord clamping on neurodevelopment and infection at four months of age: a randomised trial. | |
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MedLine Citation:
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PMID: 23336628 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G and symptoms of infection during the first four months of life. METHODS: Full-term infants (n=382) were randomised to delayed (≥ 180 seconds) or early cord clamping (≤ 10 seconds). The Ages and Stages Questionnaire was used to assess neurodevelopment at four months. Immunoglobulin G was measured at birth, two to three days and four months. Parents recorded any symptoms indicating infection during the first four months of life. RESULTS: The total scores from the Ages and Stages Questionnaire did not differ between groups. However, the delayed cord clamping group had a higher mean (SD) score in the problem solving domain (55.3 (7.2) versus 53.5 (8.2), p=0.03) at four months and a lower mean (SD) score in the personal-social domain (49.5 (9.3) versus 51.8 (8.1), p=0.01). The immunoglobulin G level was higher in the delayed cord clamping group at two to three days (11.7 g/L versus 11.0 g/L, p=0.004), but did not differ between the groups at four months. Symptoms of infection were comparable between the groups. CONCLUSION: Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to four months of age, but may have an impact on specific neurodevelopmental domains. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica. |
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Authors:
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Ola Andersson; Magnus Domellöf; Dan Andersson; Lena Hellström-Westas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-21 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica. |
Affiliation:
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Department of Paediatrics, Hospital of Halland, Halmstad, Sweden; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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