| Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP. | |
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MedLine Citation:
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PMID: 18198397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effectin vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls (n=6, each). The treated group received 10 mg/Kg(-)/body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant (p<0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the treated group. Additionally, HDL-cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress. |
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Authors:
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Leonardo Borges Murad; Marcela Rodrigues Moreira Guimarães; Lucia Marques Vianna |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 30 ISSN: 0951-6433 ISO Abbreviation: Biofactors Publication Date: 2007 |
Date Detail:
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Created Date: 2008-01-16 Completed Date: 2008-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 13-8 Citation Subset: IM |
Affiliation:
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Laboratory of Nutritional Investigation and Degenerative-Chronic Diseases, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro (City), Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology Antilipemic Agents / pharmacology Antioxidants / pharmacology Blood Glucose / drug effects Blood Pressure / drug effects Disease Models, Animal Lipids / blood Male Malondialdehyde / blood Oxidative Stress / drug effects* Rats Rats, Inbred SHR Ubiquinone / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Antilipemic Agents; 0/Antioxidants; 0/Blood Glucose; 0/Lipids; 1339-63-5/Ubiquinone; 542-78-9/Malondialdehyde; 55486-00-5/2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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