Document Detail

Effects of decreasing lung compliance with oleic acid on the cardiovascular response to PEEP.
MedLine Citation:
PMID:  339748     Owner:  NLM     Status:  MEDLINE    
In 12 anesthetized mongrel dogs on a constant volume ventilator, the response of the cardiovascular system to increasing positive end-expiratory pressure (PEEP) was examined before and after inducing acute lung injury with oleic acid. As PEEP was raised to approximately 16 mmHg, lung volume increased by approximately 900 ml before oleic acid and only 350 ml after. Pleural pressure increased by the same amount, indicating that both lung and chest wall compliance decreased with oleic acid. Right atrial pressure, the back pressure to venous return, also increased by the same amount. Although cardiac output at PEEP = 0 was lower after oleic acid, the relative decrements produced by increasing PEEP were the same as before oleic acid.
S M Scharf; R H Ingram
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  233     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H635-41     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Cardiovascular Physiological Phenomena*
Lung / physiology
Lung Compliance* / drug effects
Oleic Acids / pharmacology*
Oxygen / blood
Pancuronium / pharmacology
Positive-Pressure Respiration*
Pulmonary Edema / physiopathology
Venous Pressure
Reg. No./Substance:
0/Oleic Acids; 0/Pancuronium; 7782-44-7/Oxygen

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