Document Detail

Effects of decision variables and intraparietal stimulation on sensorimotor oscillatory activity in the human brain.
MedLine Citation:
PMID:  23035092     Owner:  NLM     Status:  MEDLINE    
To decide effectively, information must not only be integrated from multiple sources, but it must be distributed across the brain if it is to influence structures such as motor cortex that execute choices. Human participants integrated information from multiple, but only partially informative, cues in a probabilistic reasoning task in an optimal manner. We tested whether lateralization of alpha- and beta-band oscillatory brain activity over sensorimotor cortex reflected decision variables such as the sum of the evidence provided by observed cues, a key quantity for decision making, and whether this could be dissociated from an update signal reflecting processing of the most recent cue stimulus. Alpha- and beta-band activity in the electroencephalogram reflected the logarithm of the likelihood ratio associated with the each piece of information witnessed, and the same quantity associated with the previous cues. Only the beta-band, however, reflected the most recent cue in a manner that suggested it reflected updating processes associated with cue processing. In a second experiment, transcranial magnetic stimulation-induced disruption was used to demonstrate that the intraparietal sulcus played a causal role both in decision making and in the appearance of sensorimotor beta-band activity.
Ian C Gould; Anna C Nobre; Valentin Wyart; Matthew F S Rushworth
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2013-01-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13805-18     Citation Subset:  IM    
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MeSH Terms
Alpha Rhythm / physiology*
Beta Rhythm / physiology*
Biological Clocks / physiology*
Choice Behavior / physiology*
Feedback, Psychological / physiology
Hand / physiology
Learning / physiology
Movement / physiology*
Parietal Lobe / physiology*
Pattern Recognition, Visual / physiology
Psychomotor Performance / physiology*
Young Adult
Grant Support
083134//Wellcome Trust; 089903//Wellcome Trust; G0700399//Medical Research Council; G0802146//Medical Research Council; G0802146(89549)//Medical Research Council; //Medical Research Council; //Wellcome Trust

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