Document Detail

Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro.
MedLine Citation:
PMID:  10072920     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD).
METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles.
RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence.
CONCLUSION: [corrected] The effect of dauricine on APD depends on activation frequency.
D L Guo; F D Zeng; C J Hu
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  18     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1999-04-15     Completed Date:  1999-04-15     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  348-50     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Anti-Arrhythmia Agents / pharmacology*
Guinea Pigs
Isoquinolines / pharmacology*
Papillary Muscles / physiology*
Quinidine / pharmacology*
Sotalol / pharmacology*
Reg. No./Substance:
0/Alkaloids; 0/Anti-Arrhythmia Agents; 0/Benzylisoquinolines; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 8QTO90G5W5/dauricine; A6D97U294I/Sotalol; ITX08688JL/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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