| Effects of danazol on spermatogenesis in adult rats. | |
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MedLine Citation:
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PMID: 3088269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult male Wistar rats were treated with Danazol (4 mg/day s.c.) for 52 days. The drug produced a marked, rapid drop in serum testosterone concentrations to very low levels and caused a slower decrease in serum FSH, LH and testis weight. Flow cytometric analysis of testicular cell suspensions showed a decline in the absolute numbers of haploid cells (spermatids), tetraploid cells (mainly pachytene spermatocytes) and of cells in the S-phase of the division cycle, suggesting that Danazol inhibited proliferation of spermatogonia and/or primary spermatocytes. Histological counting of the different types of spermatogonia, however, revealed no significant change in their numbers during Danazol treatment. It is concluded that Danazol inhibited spermatogenesis primarily after the preleptotene stage of primary spermatocytes. |
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Authors:
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M J van Kroonenburgh; J L Beck; H M Vemer; C M Thomas; R Rolland; C J Herman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 77 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-07-30 Completed Date: 1986-07-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 233-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Danazol / pharmacology* Follicle Stimulating Hormone / blood Luteinizing Hormone / blood Male Organ Size / drug effects Pregnadienes / pharmacology* Rats Rats, Inbred Strains Sperm Count / drug effects Spermatogenesis / drug effects* Testis / anatomy & histology, cytology Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Pregnadienes; 17230-88-5/Danazol; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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