| Effects of daily oral administration of rifaximin and neomycin on faecal aerobic flora in rats. | |
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MedLine Citation:
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PMID: 11712867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare the influence of rifaximin and neomycin on faecal flora in rats. The study was performed on 18 Wistar rats (three groups of six male animals). Group 1 received rifaximin (50 mg kg(-1)/day), group 2, neomycin (50 mg kg(-1)/day) and group 3 was used as control. Drugs were administered orally, once daily for 3 days. Faecal specimens, collected from each rat on day 3, were cultured for the quantitative and qualitative determination of aerobic microorganisms. Rifaximin treatment produced a marked reduction in the number of total aerobic bacteria and Salmonellae; neomycin caused reduction in Salmonellae, but did not cause statistically significant changes in total aerobic bacterial count. The binding of neomycin with faeces could explain this limited activity, which does not correlate with the in vitro susceptibility of the organism affected. These results confirm that rifaximin is suitable for topical treatment to reduce selected bacterial load in the gut intestines. |
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Authors:
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P A Miglioli; F Allerberger; G B Calabrò; R M Gaion |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 44 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-19 Completed Date: 2002-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
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Languages: eng Pagination: 373-5 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Department of Pharmacology and Anaesthesiology, University of Padova, Largo E. Meneghetti 2, Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Bacterial Agents / administration & dosage* Bacteria, Aerobic / drug effects*, growth & development Colony Count, Microbial Drug Administration Schedule Feces / microbiology* Male Neomycin / administration & dosage* Rats Rats, Wistar Rifamycins / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Rifamycins; 1404-04-2/Neomycin; 88747-56-2/rifaximin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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