Document Detail


Effects of cytokines on the pituitary-adrenal axis in cancer patients.
MedLine Citation:
PMID:  8301155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines, which include interferons (IFNs), interleukins (ILs), and tumor necrosis factor (TNF), are immunoregulatory proteins produced by lymphocytes and inflammatory cells. Several cytokines, most noteworthy IFNs and ILs, stimulate glucocorticoid secretion. In this study, the effects of variable doses and repetitive administration of IFNs and TNF on secretion of pituitary hormones and cortisol were measured. Patients were given for a period of 15 days on alternating days injections of IFN-beta (IFN-beta ser), 90 or 450 x 10(6) IU, IFN-gamma, 0.1-100 x 10(6) IU, or TNF 125-275 micrograms/m2. Sixty to 120 min after IFN-beta ser injection median levels of cortisol, adrenocorticotropin (ACTH), prolactin (PRL), and growth hormone (GH) rose two-fold. Urinary free cortisol excretion increased significantly during the day following IFN-beta ser administration. IFN-gamma > or = 30 x 10(6) IU caused a comparable rise in plasma cortisol. TNF induced two- to four-fold increases in ACTH and cortisol. The fact that increased cortisol secretion was associated with a rise in the level of ACTH as well as PRL and GH suggests that the cytokines increased cortisol by stimulating the anterior pituitary. The hormonal response induced by cytokines was unrelated to their pyrogenic effect, undiminished with repetitive treatment, and not dose-dependent above a threshold level. These observations reinforce the concept of a physiologic link between the immune system and the hypothalamic-pituitary-adrenal (HPA) axis.
Authors:
W E Nolten; D Goldstein; M Lindstrom; M V McKenna; I H Carlson; D L Trump; J Schiller; E C Borden; E N Ehrlich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of interferon research     Volume:  13     ISSN:  0197-8357     ISO Abbreviation:  J. Interferon Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-03-07     Completed Date:  1994-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100396     Medline TA:  J Interferon Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Wisconsin, Madison.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / secretion
Adult
Aged
Cytokines / administration & dosage*
Dose-Response Relationship, Drug
Drug Administration Schedule
Growth Hormone / secretion
Humans
Hydrocortisone / secretion*
Interferon-beta / administration & dosage
Middle Aged
Neoplasms / drug therapy*,  physiopathology
Pituitary Hormones / secretion*
Pituitary-Adrenal System / drug effects*
Prolactin / secretion
Chemical
Reg. No./Substance:
0/Cytokines; 0/Pituitary Hormones; 145155-23-3/interferon beta-1b; 145258-61-3/interferon beta 1a; 50-23-7/Hydrocortisone; 77238-31-4/Interferon-beta; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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