| Effects of cyclosporine on the production of the reactive oxygen species in the glial cells. | |
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MedLine Citation:
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PMID: 18929851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: After organ transplantation, some patients suffer mild neurological symptoms such as tremor to severe complications including seizures and encephalopathy. Among the immunosuppressants, cyclosporine (CsA) can induce neurological side effects. However, the mechanisms of encephalopathy by CsA are not fully understood. We measured the production of reactive oxygen species (ROS) in the glioma cells after CsA treatment. METHODS: CsA (2.5 mmol/L) added to glioma cells was incubated for 60 minutes at 37 degrees C. ROS production was evaluated by measuring the fluorescent product from the oxidation of an oxidant-sensitive 2',7'-dichlorofluorescin using VICTOR3 multilabel counter. RESULTS: CsA resulted in ROS production by glioma cells. The ROS production increased with the time of exposure to CsA. CONCLUSIONS: These findings indicated that CsA may contribute to neurological side effects via ROS production. |
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Authors:
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K C Mun; K T Lee; H J Choi; K B Jin; S Y Han; S B Park; H C Kim; E Y Ha; Y H Kim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation proceedings Volume: 40 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2742-3 Citation Subset: IM |
Affiliation:
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Dongsan Kidney Institute and Chronic Disease Research Center, Keimyung University, Daegu, Korea. mun@dsmc.or.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclosporine / pharmacology* Free Radicals / metabolism Glioma / metabolism* Kinetics Rats Reactive Oxygen Species / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Reactive Oxygen Species; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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