| Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs. | |
| | |
MedLine Citation:
|
PMID: 1332014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of cyclooxygenase and lipoxygenase inhibitors of digoxin-induced arrhythmias and haemodynamics were studied in guinea-pigs. ECG, mean arterial blood pressure heart rate, pressure rate index and arrhythmias were recorded, starting 15 min before digoxin administration and continuing for 30 min afterwards. The cyclooxygenase inhibitor aspirin (50 mg kg-1) and the dual cyclooxygenase/lipoxygenase inhibitor BW 755C (0.25-10.0 mg kg-1) were found to produce a significant protection against the arrhythmias, whereas aspirin (100 mg kg-1) and CGS 8515 were found to be ineffective. SK&F 104 353, a potent and selective peptidoleukotriene receptor antagonist significantly attenuated the arrhythmias and mortality in a dose-dependent manner. It is concluded that production of both cyclooxygenase and lipoxygenase metabolites could favour the occurrence and/or the maintenance of digoxin-induced cardiac toxicity. |
| | |
Authors:
|
I Kanzik; I Cakici; S Ersoy; M Ark; N Abacioglu; H Zengil |
Related Documents
:
|
6206324 - In vivo comparison of the renin inhibitor h77 with the angiotensin-converting enzyme in... 14564134 - The differences between ace inhibitor-treated and calcium channel blocker-treated hyper... 7533224 - Twenty-four-hour blood pressure profiles in patients with mild-to-moderate hypertension... 6313304 - Enalapril (mk-421), a new angiotensin-converting enzyme inhibitor. acute and chronic ef... 21924634 - Pulse-pressure variation predicts fluid responsiveness during heart displacement for of... 8938854 - Cardiac performance in conscious healthy dogs during dobutamine infusion. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 26 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1992 Oct-Nov |
Date Detail:
|
Created Date: 1992-12-22 Completed Date: 1992-12-22 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 305-16 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
/
pharmacology Animals Anthranilic Acids / pharmacology Arachidonic Acids / physiology* Arrhythmias, Cardiac / chemically induced*, physiopathology*, prevention & control Aspirin / pharmacology Blood Pressure / drug effects Cyclooxygenase Inhibitors / pharmacology* Dicarboxylic Acids / pharmacology Digoxin / antagonists & inhibitors, toxicity* Female Guinea Pigs Heart Rate / drug effects Hemodynamics / drug effects* Lipoxygenase Inhibitors / pharmacology* Male Naphthoquinones / pharmacology Receptors, Immunologic / antagonists & inhibitors Receptors, Leukotriene |
| Chemical | |
Reg. No./Substance:
|
0/Anthranilic Acids; 0/Arachidonic Acids; 0/Cyclooxygenase Inhibitors; 0/Dicarboxylic Acids; 0/Lipoxygenase Inhibitors; 0/Naphthoquinones; 0/Receptors, Immunologic; 0/Receptors, Leukotriene; 107023-41-6/pobilukast; 114832-13-2/methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate; 20830-75-5/Digoxin; 50-78-2/Aspirin; 66000-40-6/4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Colonic diverticula. When complications require surgery and when they don't.
Next Document: Effects of androgen treatment on adenylate cyclase system in rat hepatic membranes.