Document Detail

Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs.
MedLine Citation:
PMID:  1332014     Owner:  NLM     Status:  MEDLINE    
Effects of cyclooxygenase and lipoxygenase inhibitors of digoxin-induced arrhythmias and haemodynamics were studied in guinea-pigs. ECG, mean arterial blood pressure heart rate, pressure rate index and arrhythmias were recorded, starting 15 min before digoxin administration and continuing for 30 min afterwards. The cyclooxygenase inhibitor aspirin (50 mg kg-1) and the dual cyclooxygenase/lipoxygenase inhibitor BW 755C (0.25-10.0 mg kg-1) were found to produce a significant protection against the arrhythmias, whereas aspirin (100 mg kg-1) and CGS 8515 were found to be ineffective. SK&F 104 353, a potent and selective peptidoleukotriene receptor antagonist significantly attenuated the arrhythmias and mortality in a dose-dependent manner. It is concluded that production of both cyclooxygenase and lipoxygenase metabolites could favour the occurrence and/or the maintenance of digoxin-induced cardiac toxicity.
I Kanzik; I Cakici; S Ersoy; M Ark; N Abacioglu; H Zengil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  26     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1992 Oct-Nov
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-16     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey.
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MeSH Terms
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine / pharmacology
Anthranilic Acids / pharmacology
Arachidonic Acids / physiology*
Arrhythmias, Cardiac / chemically induced*,  physiopathology*,  prevention & control
Aspirin / pharmacology
Blood Pressure / drug effects
Cyclooxygenase Inhibitors / pharmacology*
Dicarboxylic Acids / pharmacology
Digoxin / antagonists & inhibitors,  toxicity*
Guinea Pigs
Heart Rate / drug effects
Hemodynamics / drug effects*
Lipoxygenase Inhibitors / pharmacology*
Naphthoquinones / pharmacology
Receptors, Immunologic / antagonists & inhibitors
Receptors, Leukotriene
Reg. No./Substance:
0/Anthranilic Acids; 0/Arachidonic Acids; 0/Cyclooxygenase Inhibitors; 0/Dicarboxylic Acids; 0/Lipoxygenase Inhibitors; 0/Naphthoquinones; 0/Receptors, Immunologic; 0/Receptors, Leukotriene; 107023-41-6/pobilukast; 114832-13-2/methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate; 20830-75-5/Digoxin; 50-78-2/Aspirin; 66000-40-6/4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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