| Effects of cyclooxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep. | |
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MedLine Citation:
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PMID: 6808526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary release of thromboxanes and prostaglandins occurs during the first hour after endotoxin infusion in sheep concomitant with transient, severe pulmonary hypertension (phase I) and followed by a prolonged period of increased lung vascular permeability (phase II) characterized by moderately elevated pulmonary artery pressure and high flow of protein-rich lung lymph. Indomethacin and meclofenamate both inhibited phase I pulmonary hypertension but did not prevent later increases in pulmonary artery pressure and lung lymph flow to levels seen with endotoxin alone in the same sheep. Indomethacin significantly exaggerated phase II lung lymph flow (endotoxin = 19 +/- ml/hr; indomethacin + endotoxin = 24 +/- 4 ml/hr, p less than 0.05), and meclofenamate enhanced phase II lymph protein clearance (endotoxin = 12.9 +/- 1.5 ml/hr; meclofenamate + endotoxin = 17.1 +/- 2.5 ml/hr, p less than 0.05). Hypoxemia seen with endotoxin alone was inhibited by meclofenamate. These data indicate that during endotoxemia cyclooxygenase products mediate phase I pulmonary hypertension. Inhibitors of cyclooxygenase prevent ventilation perfusion imbalance that results in endotoxin induced hypoxemia. Exaggeration of phase II lymph responses by cyclooxygenase inhibitors suggests that prostaglandin synthesis moderates phase II or that lipoxygenation products contribute to the phase II increased permeability response. |
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Authors:
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M L Ogletree; K L Brigham |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 8 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 489-502 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Capillary Permeability / drug effects Cyclooxygenase Inhibitors* Endotoxins / pharmacology* Escherichia coli* Hypertension, Pulmonary / chemically induced Indomethacin / pharmacology Lung / blood supply* Lymph / physiology Meclofenamic Acid / pharmacology Pulmonary Artery / physiology Sheep / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Endotoxins; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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