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Effects of cromolyn sodium on isolated rat's trachea.
MedLine Citation:
PMID:  22852116     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Cromolyn sodium (cromolyn) effectively inhibits both antigen- and exercise-induced asthma when used as an aerosol. Intranasal cromolyn is also recommended for preventing and treating allergic rhinitis. By inhibiting the degranulation of sensitized mast cells, cromolyn reduces the release of mediators that trigger inflammation and the allergic response. The precise pharmacologic activity of cromolyn has not been fully elucidated. This study evaluated the effect of cromolyn on isolated rat's trachea. The following assessments of cromolyn were performed: (1) effect on tracheal resting tension, (2) effect on contraction caused by 10(-6) M of methacholine as a parasympathetic mimetic, and (3) effect of the drug on electrically induced tracheal contractions. The results indicated cromolyn could inhibit electrical field stimulation-induced spike contraction when the preparation was increased to 10(-4)M. Adding cromolyn at doses of ≥10(-8) M did not elicit a relaxation or contraction response to 10(-6) M of methacholine-induced contraction. It alone had a minimal effect on the basal tension of the trachea as the concentration increased. This study indicates cromolyn had no cholinergic or anticholinergic effect and high concentrations of cromolyn might actually inhibit parasympathetic function of the trachea. Inhibiting parasympathetic function of the trachea through stabilizing the presynaptic nerve by cromolyn may be responsible for protecting patients against antigen- and exercise-induced asthma.
Authors:
Yuan-Yung Lin; Ying-Liang Chou; Yueng-Hsiang Chu; Chi-Chung Wu; Jia-Yi Wang; Hsing-Won Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy & rhinology (Providence, R.I.)     Volume:  2     ISSN:  2152-6567     ISO Abbreviation:  Allergy Rhinol (Providence)     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-10-04     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101570968     Medline TA:  Allergy Rhinol (Providence)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e46-50     Citation Subset:  -    
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