Document Detail

Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats.
MedLine Citation:
PMID:  16649553     Owner:  NLM     Status:  MEDLINE    
Crocetin, a carotenoid isolated from the Chinese herbal medicine Crocus sativus L. (Saffron), has been shown to have cardiovascular protective effects. The present study investigated the protective action of the antioxidant crocetin against cardiac hypertrophy induced by norepinephrine (NE). This was evaluated by assaying for pathological histological changes with an optical microscope and cell image analysis system. Lipid peroxidation was quantified using thiobarbituric acid-reactive substances (TBARS). Myocardial superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and myocardial catalase (CAT) activities were assayed to evaluate the antioxidant capacity. After long term treatment with NE, antioxidant enzymatic activities were significantly decreased, while products of lipid peroxidation increased. Crocetin markedly reduced the content of lipid peroxidation (LPO), increased the GSH-Px and SOD activity in cardiac hypertrophy, and significantly improved the myocardial pathological histological changes induced by NE. These results suggest that the cardioprotective effects of crocetin are related to modulation of endogenous antioxidant enzymatic activities. Comparing crocetin with captopril, our results indicated that antioxidant activity is an important factor in the therapy of cardiac hypertrophy, but as an antioxidant only, its effects may be limited.
Xiang-Chun Shen; Zhi-Yu Qian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  61     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-02     Completed Date:  2006-05-30     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  348-52     Citation Subset:  IM    
Research Division of Basic and Clinical Pharmacology, Guiyang Medical College, Guiyang, PR China.
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MeSH Terms
Adrenergic alpha-Agonists*
Antioxidants / pharmacology*
Cardiomegaly / chemically induced*,  enzymology*,  pathology
Carotenoids / pharmacology*
Catalase / metabolism
Free Radical Scavengers / pharmacology
Glutathione Peroxidase / metabolism
Lipid Peroxidation / drug effects
Myocardium / enzymology,  pathology
Organ Size / drug effects
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Antioxidants; 0/Free Radical Scavengers; 0/Thiobarbituric Acid Reactive Substances; 27876-94-4/crocetin; 36-88-4/Carotenoids; 51-41-2/Norepinephrine; EC; EC Peroxidase; EC Dismutase

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