| Effects of coumadin on the resolution of canine venous thrombi. | |
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MedLine Citation:
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PMID: 3941546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental thrombosis of the inferior vena cava was induced in 39 dogs to create a thrombus that could be embolized to a Greenfield filter for measurement of thrombolytic activity. In the series of 17 control animals, thrombus weight had decreased from 0.871 +/- 0.10 g to 0.477 +/- 0.08 g (P less than 0.05) at 2 weeks and from 0.884 +/- 0.097 g to 0.106 +/- 0.025 g (P less than 0.001) at 4 weeks representing 56 and 12%, respectively, of initial weight. In the series of 22 animals treated with coumadin, the resolution in thrombus weight was from 0.849 +/- 0.13 g to 0.171 +/- 0.14 g (P less than 0.02) at 2 weeks and from 1.031 +/- 0.34 g to 0.013 +/- 0.013 g (P less than 0.05) at 4 weeks representing 20 and 1%, respectively, of initial weight. These results show that in this model where venous flow is preserved around a trapped thrombus, lysis proceeds at a significant rate, yet can be accelerated by therapeutic levels of coumadin. |
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Authors:
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M J Hoffman; J R Stewart; L J Greenfield |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of surgical research Volume: 40 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-02-17 Completed Date: 1986-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Drug Evaluation Thrombophlebitis / drug therapy*, pathology Time Factors Warfarin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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