| Effects of cortisol and aminophylline upon survival, pulmonary mechanics, and secreted phosphatidyl choline of prematurely delivered rabbits. | |
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MedLine Citation:
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PMID: 643375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rabbits delivered at 27.0 days of gestation were studied after administration of cortisol (2 mg/kg/day), aminophylline (6.25 mg/kg/day), or sterile saline to the does on days 24-26 of gestation. Survival at 60 min was 52.9% in the aminophylline-treated group and 22.2% in the control and cortisol-treated groups with all animals being in a warm, oxygen-enriched environment and receiving frequent tactile stimulation. Lung volume at 30 cm H2O was lower in the cortisol-treated group than in the controls or aminophylline-treated group in animals surviving for 60 min (Table 2). The aminophylline-treated group retained significantly more gas at low pressures on the deflation curve (Table 2) and had significantly more phosphatidylcholine recovered in lung lavage fluid (Table 3) than the other groups. Aminophylline appears to have enhanced lung maturation better than cortisol in this experimental model. |
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Authors:
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C T Barrett; A Sevanian; D L Phelps; C Gilden; S A Kaplan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 12 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1978 Jan |
Date Detail:
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Created Date: 1978-06-17 Completed Date: 1978-06-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 38-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Monophosphate
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metabolism Aminophylline / pharmacology* Animals Hydrocortisone / pharmacology* Lung / drug effects, growth & development*, secretion Lung Volume Measurements Phosphatidylcholines / analysis, secretion Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 317-34-0/Aminophylline; 50-23-7/Hydrocortisone; 61-19-8/Adenosine Monophosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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