Document Detail

Effects of corticotropin-releasing factor (CRF) and opiates on amphibian locomotion.
MedLine Citation:
PMID:  2161698     Owner:  NLM     Status:  MEDLINE    
Male rough-skinned newts (Taricha granulosa) were used as a model for the study of the neuroendocrine regulation of locomotion. Intracerebroventricular (i.c.v.) injections of nanogram quantities of corticotropin-releasing factor (CRF) dose-dependently increased locomotion as measured in a circular open-field test arena. In other studies animals received intraperitoneal (i.p.) injections of saline or naloxone, a synthetic opioid antagonist, followed by i.c.v. injections of saline or CRF. With 1-min intervals between injections, neither i.p. saline nor naloxone injections modified the stimulatory effects of CRF injections on locomotor activity. In contrast, with 20-min intervals between injections, the naloxone-plus-CRF injected newts displayed more locomotor activity than the saline-plus-CRF injected newts, suggesting that the opioid system modulated the behavioral effects of CRF. An i.p. injection of bremazocine, an opiate kappa-receptor agonist, suppressed spontaneous locomotion but not CRF-induced locomotion. In contrast, an i.p. injection of morphine, an opiate mu-receptor agonist, did not affect spontaneous locomotion but reduced CRF-induced locomotion, indicating further that the opioid system may modulate the behavioral effects of CRF in this amphibian. The present study provides the first evidence that both CRF and opioids may be involved in the regulation of amphibian locomotor activity.
C A Lowry; P Deviche; F L Moore
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  513     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-17     Completed Date:  1990-07-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  94-100     Citation Subset:  IM    
Department of Zoology, Oregon State University, Corvallis 97331.
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MeSH Terms
Benzomorphans / pharmacology
Corticotropin-Releasing Hormone / pharmacology*
Dose-Response Relationship, Drug
Locomotion / drug effects*
Morphine / pharmacology
Naloxone / pharmacology
Receptors, Opioid / drug effects,  physiology*
Receptors, Opioid, kappa
Receptors, Opioid, mu
Salamandridae / physiology*
Grant Support
Reg. No./Substance:
0/Benzomorphans; 0/Receptors, Opioid; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; 465-65-6/Naloxone; 57-27-2/Morphine; 75684-07-0/bremazocine; 9015-71-8/Corticotropin-Releasing Hormone

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