Document Detail


Effects of corticosteroid inhalation therapy on the deposition pattern of Tc-99m human serum albumin radioaerosols in asthma.
MedLine Citation:
PMID:  7564487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluated the effects of steroid inhalation on the deposition pattern of Tc-99m human serum albumin (Tc-99m HSA) radioaerosols in 25 asthma patients. A total of 12 normal controls also underwent the same examination. The pattern of radioaerosol deposition was quantitatively evaluated as the percentage of total deposition (PTD) in the central, intermediate, and peripheral regions of the right lung. The baseline PTD was calculated before and after the administration of a 1-week course of inhalation therapy of 0.05 mg beclomethasone dipropionate four times daily. There were significant differences in PTD between normal controls and asthma patients. Significant differences were also found before and after corticosteroid inhalation therapy in asthma patients. In conclusion, a week-long course of beclomethasone dipropionate inhalation therapy does influence the deposition patterns of aerosols in asthma patients, based on the findings of Tc-99m HSA radioaerosol inhalation lung scintigraphy.
Authors:
C H Kao; H T Lin; S L Yu; S J Wang; J L Lan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lung     Volume:  173     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Adult
Aged
Airway Resistance / drug effects,  physiology
Anti-Asthmatic Agents / administration & dosage*,  pharmacokinetics
Asthma / drug therapy*,  radionuclide imaging
Beclomethasone / administration & dosage*,  pharmacokinetics
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Technetium Tc 99m Aggregated Albumin / diagnostic use
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Technetium Tc 99m Aggregated Albumin; 4419-39-0/Beclomethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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