Document Detail


Effects of coronary ligation of the chromically sympathectomized dog ventricle.
MedLine Citation:
PMID:  696884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiac response to acute coronary occlusion was studied after chronic ventricular sympathectomy. Infarct size was measured using nitro blue tetrazolium. In 11 control dogs, 8 dogs with ventricles sympathectomized 2 wk earlier, and 5 sham-operated dogs, mean infarct size was 20.0%, 8.9%, and 20.4% of the left ventricular weight, respectively. Infarct size in sympathectomized ventricles was significantly less than in control or sham-operated hearts (P less than 0.05). Left ventricular perfusion before and after coronary occlusion was measured in 10 controls and 7 sympathectomized ventricles using tracer microspheres. Preocclusion flow values in chronically sympathectomized ventricles were approximately 30-40% less than in controls even though arterial pressure and heart rate were no different, suggesting an increased efficiency. Furthermore, after coromanary occlusion, collateral perfusions in the central and peripheral ischemic zones of the sympathectomized ventricles were 200-400% of those in nonsympathectomized ventricles. When collateral perfusion was related to the respective preocclusion flows, the difference between control and sympathectomized ventricles was even greater. Thus, chronic ventricular sympathectomy results in reduced infarct size, and this effect may be due to a reduced flow demand as well as to an increased collateral perfusion.
Authors:
C E Jones; L Y Beck; E DuPont; G E Barnes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  235     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H429-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Collateral Circulation
Coronary Circulation
Dogs
Electric Stimulation
Female
Heart / physiopathology*
Heart Rate
Heart Ventricles / innervation*
Male
Microspheres
Myocardial Infarction / physiopathology*
Stellate Ganglion / physiopathology
Sympathectomy
Vagus Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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