Document Detail

Effects of coronary collaterals on regional myocardial function during temporary coronary occlusion and hypoxic coronary perfusion.
MedLine Citation:
PMID:  3599410     Owner:  NLM     Status:  MEDLINE    
The effects of coronary collaterals on regional myocardial function during temporary ischemia and hypoxia were studied in 12 open-chest dogs. Using an ultrasonic dimension gauge, systolic segment shortening in the left anterior descending coronary artery (LAD) area was measured at 1 min after the following three experimental conditions: LAD occlusion and LAD hypoxic perfusion with nonoxygenated solutions at two different pressures (60 mmHg and 120 mmHg). Collateral function was assessed by both LAD diastolic retrograde pressure and the percentage of increase in left circumflex coronary flow at 1 min after LAD occlusion. Systolic segment shortening decreased less with hypoxic perfusion than with occlusion, however, this beneficial effect on regional contraction was greater at a perfusion pressure of 60 mmHg than at one of 120 mmHg. The magnitude of decrease of systolic shortening was variable among individual dogs but correlated linearly with each of the two collateral function indexes, not only during occlusion but also during hypoxic perfusion. In conclusion, the preventive effect of hypoxic coronary perfusion on the early decline of regional myocardial function, in comparison to the changes seen during ischemia, may depend on coronary collaterals in addition to its washout effect on metabolites. In order to maintain myocardial function, perfusion pressure should be at an optimal level.
S Ohtsuka; M Kakihana; Y Sugishita; I Ito; M Saito
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  28     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-08-14     Completed Date:  1987-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  229-41     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Collateral Circulation*
Coronary Circulation*
Coronary Disease / physiopathology*
Heart / physiopathology*
Perfusion / instrumentation,  methods
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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