Document Detail

Effects of corneal thickness on the intraocular penetration of travoprost 0.004%.
MedLine Citation:
PMID:  22562189     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness.
METHODS: Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enrolled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry.
RESULTS: Mean AL-5848 concentrations were 3.27±2.03 ng/ml in Group I (CCT<511 microns), 3.27±2.44 ng/ml in Group II (CCT≥511 and ≤574 microns), and 2.73±2.15 ng/ml in Group III (CCT>574 microns), indicating no significant differences among the groups.
CONCLUSIONS: We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug.
J M Martinez-de-la-Casa; O Rayward; F Saenz-Frances; E Santos-Bueso; C Mendez-Hernandez; R Herrero-Vanrell; J Garcia-Feijoo; J Garcia-Sanchez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-04
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-09-28     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  972-5     Citation Subset:  IM    
Servicio de Oftalmologia, Hospital Clinico San Carlos, Departamento de Oftalmologia, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos, Madrid, Spain.
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MeSH Terms
Antihypertensive Agents / pharmacokinetics*,  therapeutic use
Aqueous Humor / metabolism*
Cloprostenol / analogs & derivatives*,  pharmacokinetics,  therapeutic use
Cornea / anatomy & histology*,  metabolism
Glaucoma / drug therapy,  metabolism*
Reg. No./Substance:
0/Antihypertensive Agents; 157283-68-6/travoprost; 40665-92-7/Cloprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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