Document Detail

Effects of contrast media on the conducting system of the heart. Mechanism of action and identification of toxic component.
MedLine Citation:
PMID:  887747     Owner:  NLM     Status:  MEDLINE    
Infusion of progressive volumes of meglumine sodium diatrizoate (Renografin 76) into the arteries to the sinoatrial and atrioventricular nodes in anesthetized dogs produced a dose rate-dependent decrease in heart rate and an increase in "PR interval." At high dose rates, Renografin 76 caused sinus arrest and complete heart block in 50% and 70% of the animals, respectively. Saline and meglumine solutions (0.939 M) equiosmolar with Renografin 76 produced similar effects. Infusions of metrizamide (equal in iodine content with Renografin 76), dextrose solution (0.939 M), and autologous blood each had substantially less effects. Contrast media have a direct inhibitory action on sinoatrial automaticity and atrioventricular conductivity which is dependent on ionic strength, not iodine content.
C B Higgins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  124     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-09-29     Completed Date:  1977-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  599-606     Citation Subset:  AIM; IM    
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MeSH Terms
Atrioventricular Node / drug effects
Contrast Media / toxicity*
Depression, Chemical
Diatrizoate / analogs & derivatives*
Diatrizoate Meglumine / toxicity*
Dose-Response Relationship, Drug
Heart Conduction System / drug effects*
Heart Rate / drug effects*
Metrizamide / toxicity
Osmolar Concentration
Sinoatrial Node / drug effects
Stimulation, Chemical
Reg. No./Substance:
0/Contrast Media; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 31112-62-6/Metrizamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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