Document Detail

Effects of continuous tube feeding of dietary fat emulsions on eicosanoid production and on fatty acid composition during an acute septic shock in rats.
MedLine Citation:
PMID:  7918617     Owner:  NLM     Status:  MEDLINE    
The effects of a short-term (5 days) continuous intragastric tube feeding of diets containing n - 6 polyunsaturated fatty acids (PUFA) from safflower oil (SO) or n - 3 PUFA from menhaden oil (MO) on the production of proinflammatory mediators, and on the number of animals surviving after an intravenous injection of lipopolysaccharide (LPS) were investigated in rats. The phospholipid fatty acid composition of cell membranes from several organs and of plasma were also analyzed. No marked differences in the number of animals surviving or in the production of tumor necrosis factor-alpha were observed between the 2 groups of animals. However, 90 min after LPS exposure the plasma levels of prostaglandin (PG) E2 and 6-keto-PGF1 alpha decreased significantly (40% and 60%, respectively) for the group of rats fed MO diet compared to those fed SO diet (P < 0.05). Following continuous infusion of liquid MO diet, the amount of arachidonic acid (AA) detected was significantly lower in plasma (23%), spleen (43%), lungs (41%), and liver (38%), but was unchanged in the heart tissues. The percent of eicosapentaenoic acid (EPA) incorporated into phospholipids of plasma, spleen, lungs, liver, and heart were 7.6, 4.4, 2.1, 7.2, and 1.1%, respectively. These data indicate that after continuous MO feeding, a significant decrease in the production of proinflammatory eicosanoids was associated with a marked reduction in AA content. Further, these data suggest that nutritional intervention may have a therapeutic potential to ameliorate clinical symptoms due to excessive productions of eicosanoids during acute septic complications.
T Utsunomiya; S R Chavali; W W Zhong; R A Forse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1214     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-23     Completed Date:  1994-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Department of Surgery, New England Deaconess Hospital, Boston, MA.
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MeSH Terms
Dietary Fats, Unsaturated / administration & dosage*,  pharmacology
Dinoprostone / biosynthesis
Eicosanoids / biosynthesis*,  chemistry
Enteral Nutrition*
Fatty Acids / analysis*
Phospholipids / chemistry
Rats, Sprague-Dawley
Shock, Septic / metabolism,  mortality,  therapy*
Survival Rate
Tissue Distribution
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Eicosanoids; 0/Fatty Acids; 0/Lipopolysaccharides; 0/Phospholipids; 0/Tumor Necrosis Factor-alpha; 363-24-6/Dinoprostone

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