| Effects of continuous and triggered atrial overdrive pacing on paroxysmal atrial fibrillation in pacemaker patients. | |
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MedLine Citation:
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PMID: 18684247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of the study was to compare the effects of different pacing strategies to prevent paroxysmal atrial fibrillation (AF): triggered atrial overdrive pacing versus the combination of triggered and continuous overdrive pacing. METHODS: Patients with an indication for dual-chamber pacing (Selection 9000, Prevent AF; Vitatron B.V., Arnhem, the Netherlands) and a history of paroxysmal AF were randomized to triggered atrial pacing (three pacing functions, "triggered group": PAC Suppression, Post-PAC Response, and Post-Exercise Response) or to the combination of continuous (Pace Conditioning) and triggered atrial pacing (four pacing functions, "combined group"). After 3 months, there was a crossover to the other pacemaker setting. RESULTS: In 171 enrolled patients, the median AF burden of the combined group was with 2.1% versus 0.1% in the triggered group (P = 0.014). Fewer AF episodes were observed in the triggered (median: 7) than in the combined group (median: 116; P = 0.016). The combined group had more frequent atrial pacing (median 97%) than the triggered group with 85% (P < 0.001), but ventricular pacing was not significantly different with 95% and 96% in the combined and triggered group, respectively. After the crossover, the AF burden increased in the triggered group to 0.3% and decreased in the combined group to 0.4%. CONCLUSIONS: Triggered atrial pacing functions alone resulted in a low AF burden. The additional activation of continuous atrial overdrive pacing increased the percentage of atrial pacing, but had no beneficial effects on the prevention of paroxysmal AF. |
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Authors:
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Andreas Schuchert; Hans-Peter Rebeski; Thomas Peiffer; Eberhard Bub; Armin Dietz; Kai Mortensen; Mohammed Ali Aydin; John Camm; Steffen Gazarek; Thomas Meinertz; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 31 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 929-34 Citation Subset: IM |
Affiliation:
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Medical Clinic, Friedrich-Ebert Hospital, Neumünster, Germany. andreas.schuchert@fek.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Fibrillation / epidemiology*, prevention & control* Female Germany / epidemiology Humans Incidence Pacemaker, Artificial / statistics & numerical data* Risk Assessment / methods* Risk Factors |
| Investigator | |
Investigator/Affiliation:
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V Leonhardt / ; E Ebner / ; W Hartung / ; W Schneider / ; A Wilke / ; M Müller / ; A Lang / ; R C Schwerdt / ; F Schöning / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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