Document Detail

Effects of continuous trichloroethylene inhalation on different strains of mice.
MedLine Citation:
PMID:  6659966     Owner:  NLM     Status:  MEDLINE    
Seven different strains of mice (wild, C57BL, DBA, B6CBA, A/sn, NZB and NMRI) were continuously exposed to 150 ppm trichloroethylene (TCE) during 30 days. After exposure all strains showed large increases in liver weight, while changes in kidney and spleen weights were small. Plasma butyrylcholinesterase (BuChE) activity increased in males of all strains and in females of strains A/sn and NZB. The increase in the females was less than that of the corresponding males. We concluded that there are moderate, but in some cases, significant differences in TCE sensitivity between different mouse strains. The differences observed between sexes emphasizes the importance of specifying sex as well as strain when reporting on toxic effects.
P Kjellstrand; B Holmquist; N Mandahl; M Bjerkemo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  53     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  369-74     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Butyrylcholinesterase / blood
Kidney / drug effects
Liver / drug effects
Mice, Inbred Strains
Organ Size / drug effects
Species Specificity
Spleen / drug effects
Trichloroethylene / toxicity*
Reg. No./Substance:
79-01-6/Trichloroethylene; EC 3.1.1.-/Butyrylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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