Document Detail

Effects of continuous positive airway pressure after oleic acid-induced lung injury in dogs.
MedLine Citation:
PMID:  362359     Owner:  NLM     Status:  MEDLINE    
The physiologic effects of continuous positive airway pressure (CPAP) of 5,10,15, and 20 cm H2O during spontaneous ventilation were studied in six anesthetized dogs with simulated respiratory distress syndrome (RDS) induced by iv infusion of oleic acid and in three normal controls. After oleic acid, mean PaO2 dropped to 63.6 +/- 3.1 mm Hg while breathing 100% oxygen and mean shunt fraction was 48.3 +/- 3.0%. PaO2 and shunt fraction improved significantly at the two highest levels of CPAP (e.g.,PaO2 271.3 +/- 41.3 mm Hg and shunt fraction 17.8 +/-2.2% at 20 cm H2O CPAP). Mean mixed venous PO2 rose from 37.4 +/- 1.5 mm Hg with no CPAP TO 60.8 +/- 3.1 mm Hg at 20 cm H2O CPAP. Tissue oxygenation appeared to improve during CPAP, since cardiac output, oxygen delivery, and serum lactate were not significantly affected and mixed venous PO2 rose significantly. However, significant hypoventilation occurred at all but the lowest level of CPAP, mean PaCO2 rising from 44.1 +/- 1.8 mm Hg with no CPAP to 77.6 +/-6.8 mm Hg at 20 cm H2O CPAP. The hypoventilation during CPAP is consistent with increased work of breathing due to a combination of decreased lung compliance and increased dead space ventilation due to rapid, shallow breathing.
A B Osher; B Gothe; D H Simmons; B Waymost; H Green
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  12     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1979-01-15     Completed Date:  1979-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  923-6     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Infant, Newborn
Oleic Acids
Oxygen Consumption
Positive-Pressure Respiration*
Respiratory Distress Syndrome, Newborn / chemically induced,  physiopathology,  therapy*
Reg. No./Substance:
0/Oleic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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