Document Detail


Effects of continuous positive airway pressure on upper airway and respiratory muscle activity.
MedLine Citation:
PMID:  3298198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the effects of continuous positive airway pressure (CPAP) on lung volume, and upper airway and respiratory muscle activity, we quantitated the CPAP-induced changes in diaphragmatic and genioglossal electromyograms, esophageal and transdiaphragmatic pressures (Pes and Pdi), and functional residual capacity (FRC) in six normal awake subjects in the supine position. CPAP resulted in increased FRC, increased peak and rate of rise of diaphragmatic activity (EMGdi and EMGdi/TI), decreased peak genioglossal activity (EMGge), decreased inspiratory time and inspiratory duty cycle (P less than 0.001 for all comparisons). Inspiratory changes in Pes and Pdi, as well as Pes/EMGdi and Pdi/EMGdi also decreased (P less than 0.001 for all comparisons), but mean inspiratory airflow for a given Pes increased (P less than 0.001) on CPAP. The increase in mean inspiratory airflow for a given Pes despite the decrease in upper airway muscle activity suggests that CPAP mechanically splints the upper airway. The changes in EMGge and EMGdi after CPAP application most likely reflect the effects of CPAP and the associated changes in respiratory system mechanics on the afferent input from receptors distributed throughout the intact respiratory system.
Authors:
C G Alex; R M Aronson; E Onal; M Lopata
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  62     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2026-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Functional Residual Capacity
Humans
Lung Volume Measurements
Male
Positive-Pressure Respiration*
Respiration
Respiratory Muscles / physiology*
Respiratory Physiological Phenomena*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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