Document Detail

Effects of continuous positive airway pressure on blood pressure in hypertensive patients with obstructive sleep apnea: a 3-year follow-up.
MedLine Citation:
PMID:  23235356     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Several studies have reported a small yet significant decrease in blood pressure (BP) with continuous positive airway pressure (CPAP) application in patients with obstructive sleep apnea (OSA). We investigated the long-term efficiency of CPAP in the management of hypertensive patients with OSA on top of conventional antihypertensive medication.
METHODS: We followed 91 nonsleepy patients (aged 54 ± 9 years, 69 men) with essential hypertension and newly diagnosed moderate-to-severe OSA (apnea-hypopnea index, 38 ± 24 events/h on polysomnography) for a mean period of 3.1 years, after switching them to antihypertensive treatment targeting office BP less than 140/90 mmHg (<130/80 mmHg in diabetic patients). Participants were defined as on-CPAP if they adhered to CPAP treatment during the whole follow-up period (N = 41), whereas those that did not follow CPAP therapy served as controls (N = 50).
RESULTS: By the end of follow-up, on-CPAP patients and controls exhibited similar SBP and DBP levels (133 ± 12 versus 133 ± 13 mmHg, 84 ± 9 versus 85 ± 9 mmHg, respectively, P > 0.05 for all), number of patients with controlled hypertension (71 versus 70%, P > 0.05), and number of antihypertensive drugs needed to achieve BP control (2.28 ± 1.09 versus 2.11 ± 0.72, P > 0.05). In a subgroup of patients (N = 34) in whom ambulatory BP monitoring was also performed, 24-h BP levels did not differ between the two groups (125 ± 10/76 ± 7 mmHg versus 123 ± 11/75 ± 10 mmHg, P > 0.05). In multiple regression models, CPAP application was not associated with changes in BP levels.
CONCLUSION: In nonsleepy, hypertensive, OSA patients on conventional antihypertensive treatment, long-term CPAP application is not associated with lower BP levels or a need for less antihypertensive drugs for BP control.
Alexandros Kasiakogias; Costas Tsioufis; Costas Thomopoulos; Dimitrios Aragiannis; Manos Alchanatis; Dimitrios Tousoulis; Vasilios Papademetriou; John S Floras; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  31     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-07-02     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  352-60     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Continuous Positive Airway Pressure*
Follow-Up Studies
Hypertension / complications,  physiopathology*
Middle Aged
Prospective Studies
Sleep Apnea, Obstructive / complications,  therapy*
Comment In:
J Hypertens. 2014 Nov;32(11):2279   [PMID:  25271917 ]
J Hypertens. 2014 Nov;32(11):2279-80   [PMID:  25271918 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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