Document Detail

'Effects of continuous positive airway pressure on blood pressure in hypertensive patients with obstructive sleep apnea: a 3-year follow-up'
MedLine Citation:
PMID:  23235356     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: Several studies have reported a small yet significant decrease in blood pressure (BP) with continuous positive airway pressure (CPAP) application in patients with obstructive sleep apnea (OSA). We investigated the long-term efficiency of CPAP in the management of hypertensive patients with OSA on top of conventional antihypertensive medication. METHODS:: We followed 91 nonsleepy patients (aged 54 ± 9 years, 69 men) with essential hypertension and newly diagnosed moderate-to-severe OSA (apnea-hypopnea index, 38 ± 24 events/h on polysomnography) for a mean period of 3.1 years, after switching them to antihypertensive treatment targeting office BP less than 140/90 mmHg (<130/80 mmHg in diabetic patients). Participants were defined as on-CPAP if they adhered to CPAP treatment during the whole follow-up period (N = 41), whereas those that did not follow CPAP therapy served as controls (N = 50). RESULTS:: By the end of follow-up, on-CPAP patients and controls exhibited similar SBP and DBP levels (133 ± 12 versus 133 ± 13 mmHg, 84 ± 9 versus 85 ± 9 mmHg, respectively, P > 0.05 for all), number of patients with controlled hypertension (71 versus 70%, P > 0.05), and number of antihypertensive drugs needed to achieve BP control (2.28 ± 1.09 versus 2.11 ± 0.72, P > 0.05). In a subgroup of patients (N = 34) in whom ambulatory BP monitoring was also performed, 24-h BP levels did not differ between the two groups (125 ± 10/76 ± 7 mmHg versus 123 ± 11/75 ± 10 mmHg, P > 0.05). In multiple regression models, CPAP application was not associated with changes in BP levels. CONCLUSION:: In nonsleepy, hypertensive, OSA patients on conventional antihypertensive treatment, long-term CPAP application is not associated with lower BP levels or a need for less antihypertensive drugs for BP control.
Alexandros Kasiakogias; Costas Tsioufis; Costas Thomopoulos; Dimitrios Aragiannis; Manos Alchanatis; Dimitrios Tousoulis; Vasilios Papademetriou; John S Floras; Christodoulos Stefanadis
Related Documents :
7524256 - Cardiovascular effects of moderate normovolaemic haemodilution during enflurane-nitrous...
24669646 - Oral clonidine for attenuation of haemodynamic response to laryngoscopy and endotrachea...
8916826 - Epidural anesthesia and acutely increased intracranial pressure. lumbar epidural space ...
3232776 - Intra-ocular pressure changes during rapid sequence induction of anaesthesia. a compari...
4028536 - Hemodynamic advantage of combined administration of oral ibopamine and nitroprusside in...
787736 - The development of mechanical assistance to the failing human heart.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-11
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aFirst Cardiology Clinic, University of Athens Medical School, Hippokration Hospital bFirst Respiratory Medicine Department, University of Athens Medical School, Sotiria Chest Diseases Hospital, Athens, Greece cVeterans Affairs Medical Center, Cardiology Department and Georgetown, Medical Centers, Washington, District of Columbia, USA dFaculty of Medicine, University of Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diur...
Next Document:  Accuracy of the pulse delay time technique with triple cuff for objective indirect blood pressure me...