Document Detail


Effects of continuous positive airway pressure on exercise capacity in chronic heart failure patients without sleep apnea.
MedLine Citation:
PMID:  18204181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea. It is known, that there are beneficial effects on cardiac function, which might be explained by suppression of apnea and specific hemodynamic effects of CPAP. Therefore, CPAP might act as an adjunct therapy in heart failure, even in the absence of sleep apnea. In the present study, 11 patients with congestive heart failure (EF=23.1+/-6.9%) without sleep apnea (AHI 3.0+/-1.2/h) were treated with nocturnal CPAP. Cardiopulmonary exercise testing was performed at baseline and after 8.6 +/-1.3 months. All patients underwent heart catheterization and myocardial biopsy to exclude myocarditis at baseline. Five (46%) of the 11 patients did not complete the study because of poor compliance and irregular use of the CPAP device. Six (54%) of the patients used CPAP regularly (>6 h/night) and completed the study. Cardiopulmonary exercise testing showed an improvement of work load (96+/-36 Watt vs. 112+/-34 Watt; P=0.025) and VO2 peak (1227+/-443 ml vs. 1525+/-470 ml; P=0.01). Oxygen-pulse was increased, although that did not reach significance (11.2+/-4.8 ml/beat vs. 12.6+/-3.9 ml/beat). In conclusion, CPAP might have beneficial effects on exercise capacity in patients with congestive heart failure even in the absence of sleep apnea. Nevertheless, poor compliance seems to be a limiting factor.
Authors:
S Steiner; P O Schueller; C M Schannwell; M Hennersdorf; B E Strauer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  58 Suppl 5     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  665-72     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Germany. Steinest@uni-duesseldorf.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / physiology
Chronic Disease
Continuous Positive Airway Pressure*
Exercise / physiology*
Exercise Test
Female
Heart Failure / physiopathology*,  therapy*
Heart Rate / physiology
Humans
Long-Term Care
Male
Middle Aged
Oxygen / blood
Oxygen Consumption / physiology
Patient Compliance
Polysomnography
Respiratory Function Tests
Sleep Apnea, Obstructive / physiopathology
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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