Document Detail

Effects of a continuous infusion of tris(hydroxymethyl)aminomethane on acidosis, oxygen affinity, and serum osmolality.
MedLine Citation:
PMID:  8297938     Owner:  NLM     Status:  MEDLINE    
The effects of a continuous infusion of tris(hydroxymethyl)aminomethane (THAM) on pH, base excess, p50, serum osmolality, and plasma drug concentration during respiratory acidosis were studied in newborn piglets. Measurements were made during three experimental periods: (1) control period with normal blood gases; (2) hypercapnia period, and (3) hypercapnia plus THAM period (THAM infusion: 1.65 mmol/kg/h). pH decreased and paCO2 increased between control period (7.40 +/- 0.05 and 45 +/- 3 mm Hg) and hypercapnia period (7.24 +/- 0.06 and 59 +/- 2 mm Hg; p < 0.001; mean +/- SD). pH returned to baseline (7.37 +/- 0.04) during the hypercapnia plus THAM period, while paCO2 remained elevated (63 +/- 4 mm Hg). p50 increased from 30.7 +/- 5.9 to 38.3 +/- 4.7 (p < 0.05) during hypercapnia and decreased with hypercapnia plus THAM. THAM concentration and base excess increased with time and were linearly related. Serum osmolality was unchanged during the THAM infusion. We conclude that continuous infusion of THAM is effective in normalizing pH during respiratory acidosis in the piglet.
R Schneiderman; T S Rosenkrantz; I Knox; R Cramer; R Smoloski; J R Raye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  64     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-10     Completed Date:  1994-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  287-94     Citation Subset:  IM    
Department of Pediatrics, University of Connecticut Health Center, Farmington 06030.
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MeSH Terms
Acidosis, Respiratory / blood*,  metabolism*
Animals, Newborn
Blood Gas Analysis
Hydrogen-Ion Concentration
Hypercapnia / blood,  metabolism
Infusions, Intravenous
Osmolar Concentration
Oxygen / metabolism*
Tromethamine / pharmacology*
Reg. No./Substance:
77-86-1/Tromethamine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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