| Effects of continuous flow left ventricular assist device support on skin tissue microcirculation and aortic hemodynamics. | |
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MedLine Citation:
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PMID: 12558315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous flow ventricular assist devices (CFVADs) are thought to be the next generation of circulatory assist devices. With many now in various stages of development or clinical trial, it is important that the physiologic aspects of these pumps be critically analyzed. In this study, 15 calves were divided into two groups. One group received a CFVAD, and the other a sham implant. Two additional animals were used in an acute study to examine aortic blood flow patterns from a CFVAD. Tissue perfusion was measured on all animals before surgery and then weekly thereafter. Before surgery, there was no difference in hemodynamics or tissue perfusion between studied animals. Postoperatively, CFVAD animals had statistically significant increased diastolic pressure. Significantly decreased pulse pressure, pulse index, and tissue perfusion were also observed in CFVAD animals. Results from the flow pattern studies suggested that at moderate levels of pump support (40-75%), the amount of blood flow distal to the outflow graft anastomosis decreased approximately 25% because of increased regurgitant blood flow in the aorta. These results suggest that the diminished tissue perfusion is likely due to changes in aortic hemodynamics and provide some insight into the distribution of flow from CFVADs. |
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Authors:
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Kenneth N Litwak; Shin'ichiro Kihara; Marina V Kameneva; Philip Litwak; Arkady Uryash; Zhongjun Wu; Bartley P Griffith |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 49 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-01-31 Completed Date: 2003-07-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Pittsburgh, 215 McGowan Institute, 3025 E. Carson St., Pittsburgh, PA 15203, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / physiology* Blood Pressure Cardiac Output Cattle Heart-Assist Devices* Male Microcirculation Regional Blood Flow Skin / blood supply* |
| Grant Support | |
ID/Acronym/Agency:
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1R01 HL64950-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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ASAIO J. 2003 Sep-Oct;49(5):613-4; author reply 614
[PMID:
14524576
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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