Document Detail

Effects of 'contact laxatives' on intestinal and colonic epithelial cell proliferation.
MedLine Citation:
PMID:  8234428     Owner:  NLM     Status:  MEDLINE    
Experimental studies indicate that laxatives may induce epithelial damage. In addition, some laxatives induce the release of prostaglandins. Epithelial cell damage and release of prostaglandins are two pathways by which epithelial cell proliferation could be influenced. Furthermore, fermentable laxatives like lactulose may influence large intestine cell proliferation by the trophic effect of the fermentation products such as short-chain fatty acids. For these reasons an in vivo study in rats was performed to compare the short- and long-term effect of sennosides, bisacodyl, sodium picosulfate and lactulose on epithelial cell proliferation in the ileum and large intestine. Cell proliferation was examined by the BrdUrd labelling technique after 2, 6 and 12 weeks of continuous treatment. Studies in control animals show that the Labeling Index (LI) is higher in the cecum compared with other segments of the colon, and higher in the ileum than in the colon. Treatment with sennosides, bisacodyl and sodium picosulfate does not influence the LI in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with all the laxatives throughout the study. It appears therefore that 'contact' laxatives have no major influence on ileal and colonic epithelial cell proliferation and should not be regarded as tumor-promoting substances.
K Geboes; G Nijs; U Mengs; K P Geboes; A Van Damme; P de Witte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  47 Suppl 1     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-20     Completed Date:  1993-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Laboratory of Histo- and Cytochemistry, Department of Medical Research, KU Leuven, Belgium.
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MeSH Terms
Antibodies, Monoclonal
Bromodeoxyuridine / metabolism
Cathartics / pharmacology*
Cell Division
DNA / biosynthesis
DNA Replication / drug effects
Ileum / drug effects*,  pathology
Immunoenzyme Techniques
Intestinal Mucosa / cytology,  drug effects
Intestine, Large / drug effects*,  pathology
Rats, Wistar
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cathartics; 59-14-3/Bromodeoxyuridine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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