Document Detail

Effects of conjugated linoleic acid on prostaglandins produced by cells isolated from maternal intercotyledonary endometrium, fetal allantochorion and amnion in late pregnant ewes.
MedLine Citation:
PMID:  14499736     Owner:  NLM     Status:  MEDLINE    
The anticarcinogenic properties of conjugated linoleic acid (CLA) are, at least partially, attributed to its ability to interrupt the n-6 polyunsaturated fatty acid (PUFA) metabolic pathway for the biosynthesis of eicosanoids, including prostaglandins (PG). Both PGE(2) and PGF(2alpha) play key roles in parturition. In the present study, we compared the effects of CLA (a mixture of cis- and trans-9, 11- and -10, 12-octadecadienoic acid) and linoleic acid (LA) on PG production by cells isolated from maternal intercotyledonary endometrium, fetal allantochorion and amnion from late pregnant ewes. The results demonstrated that supplementation of LA and CLA significantly affected both the proportions and the amounts of PGs produced by all three tissue types. The ability of the uterus and placenta to respond to oxytocin (OT, endometrium only) and lipopolysaccharide (LPS) was also affected. LA inhibited PGE(2) and PGF(2alpha) production in the absence or presence of either oxytocin or LPS. In endometrial cells with or without oxytocin or LPS, CLA dose-dependently suppressed PGF(2alpha) generation, whereas low doses of CLA (20 microM) increased PGE(2) generation. Supplementation with CLA therefore increased the PGE(2)/PGF(2alpha) ratio in the endometrial cells. These results suggest that dietary supplementation of LA or CLA may affect both the initiation and progression of parturition.
Z Cheng; M Elmes; D R E Abayasekara; D C Wathes
Related Documents :
10230716 - Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body compo...
8747326 - Survey of the conjugated linoleic acid contents of dairy products.
2268336 - Stereochemistry of the epoxidation of fatty acids catalyzed by soybean peroxygenase.
15234996 - Biochemical and immunochemical evidences for the presence of lipoxygenase in plant mito...
8954566 - Influence of superoxide radical and hydrogen peroxide on arachidonic acid mobilization.
22118066 - Developing a strawberry yogurt fortified with marine fish oil.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1633     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-22     Completed Date:  2003-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  170-8     Citation Subset:  IM    
Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Allantois / drug effects,  metabolism
Amnion / drug effects,  metabolism
Chorion / drug effects,  metabolism
Dietary Supplements / toxicity
Dinoprost / biosynthesis
Dinoprostone / biosynthesis
Endometrium / drug effects*,  metabolism*
Extraembryonic Membranes / drug effects*,  metabolism*
Linoleic Acids / toxicity*
Parturition / drug effects,  metabolism
Prostaglandins / biosynthesis*
Reg. No./Substance:
0/Linoleic Acids; 0/Prostaglandins; 363-24-6/Dinoprostone; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthetic, non-natural sphingolipid analogs inhibit the biosynthesis of cellular sphingolipids, elev...
Next Document:  Novel polar lipids of halophilic eubacterium Planococcus H8 and archaeon Haloferax volcanii.