Document Detail

Effects of confinement (110 and 240 days) on neuroendocrine stress response and changes of immune cells in men.
MedLine Citation:
PMID:  11896029     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to evaluate the effects of long-term confinement on stress-permissive neuroendocrine and immune responses in humans. Two groups of four male subjects were confined 240 days (group 240) or 110 days (group 110) in two space modules of 100 or 200 m3, respectively. During confinement, none of the volunteers developed psychic stress as could be examined and verified by a current stress test. However, in group 240 but not in group 110, the diurnal rhythm of cortisol secretion was slightly depressed and the urine excretion of norepinephrine significantly increased. The innate part of the immune system became activated as seen by a rise in the number of circulating granulocytes and the enhanced expression of beta2-integrins. In contrast, the ratio of T-helper to T-suppressor cells decreased. All these effects, observed during confinement, were even more pronounced in both groups when values of endocrinological and immunological parameters were compared between before and 1 wk after the end of the confinement period. Hence, return to normal life exerts pronounced effects to a much higher degree, irrespective of how long or under which conditions individuals were confined. Because the delayed-type hypersensitivity skin reaction against recall antigens remained unaffected, it is to be presumed that confinement appears to induce distinct sympathoadrenergic activation and immunological changes but no clinically relevant immunosuppression.
A Choukèr; L Smith; F Christ; I Larina; I Nichiporuk; V Baranov; E Bobrovnik; L Pastushkova; K Messmer; K Peter; M Thiel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  92     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-15     Completed Date:  2002-07-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1619-27     Citation Subset:  IM; S    
Clinic of Anaesthesiology, University of Munich, 81366 Munich, Germany.
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MeSH Terms
Antigens, CD18 / analysis
Astronauts / psychology
C-Reactive Protein / metabolism
Catecholamines / blood
Confined Spaces*
Cytokines / blood
Hydrocortisone / analysis
Hypersensitivity, Delayed / immunology*,  psychology
Immunologic Memory
Leukocyte Count
Leukocytes / chemistry,  cytology,  immunology*
Macrophage-1 Antigen / analysis
Middle Aged
Neurosecretory Systems / immunology*
Prolactin / blood
Saliva / chemistry
Stress, Psychological / immunology*
Superoxides / metabolism
Reg. No./Substance:
0/Antigens, CD18; 0/Catecholamines; 0/Cytokines; 0/Macrophage-1 Antigen; 11062-77-4/Superoxides; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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