| Effects of confinement (110 and 240 days) on neuroendocrine stress response and changes of immune cells in men. | |
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MedLine Citation:
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PMID: 11896029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to evaluate the effects of long-term confinement on stress-permissive neuroendocrine and immune responses in humans. Two groups of four male subjects were confined 240 days (group 240) or 110 days (group 110) in two space modules of 100 or 200 m3, respectively. During confinement, none of the volunteers developed psychic stress as could be examined and verified by a current stress test. However, in group 240 but not in group 110, the diurnal rhythm of cortisol secretion was slightly depressed and the urine excretion of norepinephrine significantly increased. The innate part of the immune system became activated as seen by a rise in the number of circulating granulocytes and the enhanced expression of beta2-integrins. In contrast, the ratio of T-helper to T-suppressor cells decreased. All these effects, observed during confinement, were even more pronounced in both groups when values of endocrinological and immunological parameters were compared between before and 1 wk after the end of the confinement period. Hence, return to normal life exerts pronounced effects to a much higher degree, irrespective of how long or under which conditions individuals were confined. Because the delayed-type hypersensitivity skin reaction against recall antigens remained unaffected, it is to be presumed that confinement appears to induce distinct sympathoadrenergic activation and immunological changes but no clinically relevant immunosuppression. |
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Authors:
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A Choukèr; L Smith; F Christ; I Larina; I Nichiporuk; V Baranov; E Bobrovnik; L Pastushkova; K Messmer; K Peter; M Thiel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 92 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-15 Completed Date: 2002-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1619-27 Citation Subset: IM; S |
Affiliation:
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Clinic of Anaesthesiology, University of Munich, 81366 Munich, Germany. alexander.chouker@ana.med.uni-muenchen.de). |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD18 / analysis Astronauts / psychology C-Reactive Protein / metabolism Catecholamines / blood Child Confined Spaces* Cytokines / blood Humans Hydrocortisone / analysis Hypersensitivity, Delayed / immunology*, psychology Immunologic Memory Leukocyte Count Leukocytes / chemistry, cytology, immunology* Macrophage-1 Antigen / analysis Middle Aged Neurosecretory Systems / immunology* Prolactin / blood Saliva / chemistry Stress, Psychological / immunology* Superoxides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD18; 0/Catecholamines; 0/Cytokines; 0/Macrophage-1 Antigen; 11062-77-4/Superoxides; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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