Document Detail

Effects of the concentration and frequency of acid infusion on the development and maintenance of esophageal hyperalgesia in a human volunteer model.
MedLine Citation:
PMID:  18258794     Owner:  NLM     Status:  MEDLINE    
Previous studies have demonstrated that a single 30-min distal esophageal infusion of concentrated (0.15 M, pH 0.8) hydrochloric acid (HCl) induces hyperalgesia to an electrical stimulus in a human model. The aim of this study was to refine this model using physiological acid concentrations (pH 1.8-4) in repeated short exposures. Two different cohorts of 10 volunteers underwent two studies. Study 1: randomization to four 5-min distal esophageal infusions of acid (0.15 M) or saline, 1 h apart. Double-blind measurements of baseline and postexposure proximal esophageal and chest wall pain thresholds (PTs) were performed to electrical stimulation at 30-min intervals throughout the study. Study 2: randomization to four 15-min infusions of 0.15, 0.075, and 0.01 M HCl and saline. In study 1, with multiple acid infusions, a significant progressive drop in PTs was observed in both areas tested (P < or = 0.0001). In study 2, increasing acid concentrations had a significant effect over multiple time points, P < or = 0.0001. Similar initial reductions in PTs were observed for all acid concentrations compared with saline; however, hypersensitivity was shorter lasting with 0.01 M acid. In healthy subjects, esophageal hypersensitivity can be induced and maintained up to 4 h by repeated short-duration acid infusion and at physiological pH levels. This has implications for future model design and pathophysiological understanding of acid-related esophageal hypersensitivity.
Philip J Matthews; Charles H Knowles; Yang C Chua; Claire Delaney; Anthony R Hobson; Qasim Aziz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-02-07
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  294     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-09     Completed Date:  2008-05-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G914-7     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Electric Stimulation
Gastroesophageal Reflux / chemically induced*,  complications,  physiopathology
Hydrochloric Acid / administration & dosage*,  adverse effects
Hydrogen-Ion Concentration
Hyperalgesia / etiology*,  physiopathology
Infusions, Parenteral
Middle Aged
Pain Measurement
Pain Threshold
Time Factors
Grant Support
G0300195//Medical Research Council; //Medical Research Council
Reg. No./Substance:
QTT17582CB/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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