Document Detail

Effects of concentrated ambient particles on heart rate, blood pressure, and cardiac contractility in spontaneously hypertensive rats.
MedLine Citation:
PMID:  15204757     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have shown that particulate matter (PM) air pollution is associated with cardiovascular mortality and morbidity, especially for particles with aerodynamic diameters under 2.5 microm (PM(2.5)). Recent studies have revealed an association between PM pollution and autonomic functions including heart rate (HR), blood pressure (BP), and heart-rate variability. However, the association and linking mechanisms have not been clearly demonstrated in animal studies. Utilizing a novel approach that employs a mixed-effects model to overcome the problems of variations in diseased animals and circadian cycles, we have previously demonstrated an association between concentrated PM(2.5) and changes of HR and BP in pulmonary hypertensive rats. The objective of this study is to test the plausibility of this methodology and to demonstrate the particle effects under different pathophysiology. The feasibility of cardiac contractility (measured as QA interval, QAI) as an indicator for PM toxicology was also explored. Four spontaneously hypertensive (SH) rats were repeatedly exposed to concentrated PM(2.5) during spring and summer. The mass concentration of particles during the 5 h of exposure was 202.0 +/- 68.8 (mean +/- SE) and 141.0 +/- 54.9 microg/m(3) for spring and summer experiments, respectively. During spring exposures, the maximum increase of HR and mean BP noted at the end of exposure were 51.6 bpm (p <.001) and 8.7 mm Hg (p =.002), respectively. The maximum decrease of QAI noted at the same time was 1.6 ms (p =.001). Though a similar pattern was demonstrated during summer exposures, the responses were less prominent. We conclude that concentrated PM(2.5) may increase HR and mean BP and decrease QAI in SH rats. Our results also show that QAI may be used as an indicator in PM toxicology.
Chuen-Chau Chang; Jing-Shiang Hwang; Chang-Chuan Chan; Peng-Yau Wang; Tsuey-Hwa Hu; Tsun-Jen Cheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inhalation toxicology     Volume:  16     ISSN:  0895-8378     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-9     Citation Subset:  IM    
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, and Department of Anesthesiology, China Medical College Hospital, Taichung, Taiwan.
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MeSH Terms
Air Pollutants / toxicity
Air Pollution / adverse effects*
Blood Pressure / drug effects*
Heart Rate / drug effects*
Myocardial Contraction / drug effects*
Particle Size
Rats, Inbred SHR
Time Factors
Reg. No./Substance:
0/Air Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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