Document Detail


Effects of the common 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness to recombinant follicle-stimulating hormone.
MedLine Citation:
PMID:  16533336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: The common 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene is less prevalent in mothers of spontaneously conceived dichorionic twins than in those with singleton pregnancies. (Hasbargen U, Lohse P, Thaler CJ: Hum Reprod 2000; 15:2659-2662). As polyovulation is a pre-requisite for dichorionic pregnancies, we investigated whether the T allele is associated with reduced ovarian responsiveness to follicle-stimulating hormone (FSH). MATERIALS AND METHODS: We studied 105 infertility patients undergoing a total of 269 A.R.T cycles stimulated with recombinant (r)-FSH. The MTHFR 677C>T genotype was analyzed by digestion of polymerase chain reaction-amplified DNA fragments. RESULTS: Homozygous 677C patients older than 35, required significantly (P <0.02) less r-FSH and produced significantly more oocytes (P < 0.04) and higher maximal serum estradiol concentrations (P < 0.002) than heterozygous or homozygous carriers of the 677T allele. CONCLUSION: Our results suggest that, in patients of advanced reproductive age, the MTHFR 677C>T mutation affects ovarian responsiveness.
Authors:
Christian J Thaler; Helen Budiman; Heike Ruebsamen; Dorothea Nagel; Peter Lohse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  55     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology-Grosshadern, University Hospital, Ludwig-Maximilians-University, Munich, Germany. thaler@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Cytosine*
Female
Follicle Stimulating Hormone / physiology,  therapeutic use*
Humans
Infertility, Female / drug therapy,  genetics
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Mutation*
Ovary / enzymology*,  metabolism
Polymorphism, Single Nucleotide*
Prospective Studies
Recombinant Proteins / pharmacology,  therapeutic use*
Thymine*
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 65-71-4/Thymine; 71-30-7/Cytosine; 9002-68-0/Follicle Stimulating Hormone; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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