Document Detail


Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro.
MedLine Citation:
PMID:  18824210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as engineered nanoparticles (titanium dioxide and single-walled carbon nanotubes) on impulse conduction characteristics, myofibrillar structure and the formation of reactive oxygen species in patterned growth strands of neonatal rat ventricular cardiomyocytes in vitro. Diesel exhaust particles as well as titanium dioxide nanoparticles showed the most pronounced effects. We observed a dose-dependent change in heart cell function, an increase in reactive oxygen species and, for titanium dioxide, we also found a less organized myofibrillar structure. The mildest effects were observed for single-walled carbon nanotubes, for which no clear dose-dependent alterations of theta and dV/dt(max) could be determined. In addition, there was no increase in oxidative stress and no change in the myofibrillar structure. These results suggest that diesel exhaust as well as titanium dioxide particles and to a lesser extent also single-walled carbon nanotubes can directly induce cardiac cell damage and can affect the function of the cells.
Authors:
Maria Helfenstein; Michele Miragoli; Stephan Rohr; Loretta Müller; Peter Wick; Martin Mohr; Peter Gehr; Barbara Rothen-Rutishauser
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-09
Journal Detail:
Title:  Toxicology     Volume:  253     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  70-8     Citation Subset:  IM    
Affiliation:
Institute for Anatomy, Division of Histology, University of Bern, Baltzerstrasse 2, CH-3000 Bern 9, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Air Pollutants / toxicity*
Animals
Dose-Response Relationship, Drug
Microscopy, Electron, Transmission
Microscopy, Fluorescence
Microscopy, Phase-Contrast
Myocytes, Cardiac / drug effects*,  physiology,  ultrastructure
Myofibrils / drug effects,  ultrastructure
Nanoparticles / toxicity*
Nanotubes, Carbon / toxicity*
Particulate Matter / toxicity*
Rats
Reactive Oxygen Species / metabolism
Titanium / toxicity
Vehicle Emissions / toxicity*
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Nanotubes, Carbon; 0/Particulate Matter; 0/Reactive Oxygen Species; 0/Vehicle Emissions; 13463-67-7/titanium dioxide; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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