Document Detail


Effects of combined use of sildenafil citrate (Viagra) and 17beta-estradiol on ovine coronary and uterine hemodynamics.
MedLine Citation:
PMID:  15167832     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was undertaken to determine whether Viagra (Pfizer, New York, NY), a type 5 phosphodiesterase (PDE-5) inhibitor, increases baseline coronary and uterine blood flow or potentiates estrogen-induced increases in blood flow. STUDY DESIGN: Seven nonpregnant ovariectomized ewes were chronically instrumented to measure blood pressure, heart rate, cardiac output, and coronary and uterine blood flow. Estradiol-17beta (E2, 0.3 microg/kg) (Sigma Chemical Co, St Louis, Mo) and Viagra (50 mg) were intravenously administered separately or together and hemodynamic responses monitored. RESULTS: Viagra alone rapidly decreased mean arterial pressure and cardiac output while increasing heart rate and uterine blood flow. Viagra tended to decrease coronary blood flow but not significantly. E2 by itself increased coronary and uterine blood flow over a 2-hour time course, whereas mean arterial pressure, cardiac output, and heart rate remained unchanged. Administration of E2 to animals pretreated with Viagra reversed Viagra-related decrease in cardiac output and coronary blood flow, resulting in a time-related increase in both parameters over baseline values. Viagra significantly augmented estradiol-related increases in uterine blood flow. CONCLUSION: In our surgically menopausal ovine model, Viagra alone has a tendency to decrease baseline coronary blood flow, but the reduction does not reach statistical significance. The presence of estradiol reverses this Viagra-related negative trend and results in a net increase in coronary blood flow and cardiac output. Furthermore, Viagra significantly augments baseline and estrogen-induced increases in uterine blood flow suggesting the presence of PDE-5 in the ovine uterine vasculature.
Authors:
Willie D Zoma; R Scott Baker; Kenneth E Clark
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  190     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-07-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1291-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Blood Pressure Determination
Cardiac Output / drug effects
Coronary Circulation / drug effects
Disease Models, Animal
Drug Therapy, Combination
Estradiol / pharmacology*
Female
Heart Rate / drug effects
Hemodynamics / drug effects*,  physiology*
Injections, Intravenous
Piperazines / pharmacology*
Probability
Purines
Sensitivity and Specificity
Sheep, Domestic
Sulfones
Uterus / blood supply
Grant Support
ID/Acronym/Agency:
HL-49901/HL/NHLBI NIH HHS; HL-50880/HL/NHLBI NIH HHS; HL-62490/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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