| Effects of combined treatment with vitamins C and E on passive avoidance learning and memory in diabetic rats. | |
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MedLine Citation:
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PMID: 20085822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Learning and memory deficits occur in diabetes mellitus. Although the pathogenesis of cognitive impairment in diabetes has not been fully elucidated, factors such as metabolic impairments, vascular complications and oxidative stress are thought to play possible roles. Here we investigated the effect of chronic treatment with vitamin C (50mg/kg, p.o), vitamin E (100mg/kg, p.o) and both together on passive avoidance learning (PAL) and memory in male Wistar control and diabetic rats. Treatments were begun at the onset of hyperglycemia. Passive avoidance learning was assessed 30 days later. Retention was tested 24h after training. At the end, animals were weighed and blood samples were drawn for plasma glucose measurement. Diabetes caused impairment in acquisition and retrieval processes of PAL and memory. The combination of vitamin C and E improved learning and memory in controls and reversed learning and memory deficits in diabetic rats. Combined treatment also affected the body weight and plasma glucose level of diabetic treated animals compared to untreated diabetic animals. Hypoglycemic effects and antioxidant properties of the vitamins may be involved in the nootropic effect of such treatment. These results show that combined treatment with vitamins C and E improved PAL and memory of control rats. In addition, combined vitamins administration to rats for 30 days from onset of diabetes alleviated the negative influence of diabetes on learning and memory. Therefore, combined vitamins treatment may provide a new potential alternative for prevention of impaired cognitive functions associated with diabetes and may warrant further clinical study. |
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Authors:
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Parisa Hasanein; Siamak Shahidi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-18 |
Journal Detail:
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Title: Neurobiology of learning and memory Volume: 93 ISSN: 1095-9564 ISO Abbreviation: Neurobiol Learn Mem Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: United States |
Other Details:
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Languages: eng Pagination: 472-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biology, School of Basic Sciences, Bu-Ali Sina University, Hamadan, Iran. p.hasanein@basu.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascorbic Acid / administration & dosage, therapeutic use* Avoidance Learning / drug effects* Blood Glucose / analysis, drug effects Body Weight / drug effects Diabetes Mellitus, Experimental / blood, drug therapy* Drug Therapy, Combination Learning Disorders / blood, drug therapy Male Memory / drug effects* Memory Disorders / blood, drug therapy Neuropsychological Tests Nootropic Agents / administration & dosage, therapeutic use* Rats Rats, Wistar Time Factors Vitamin E / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Nootropic Agents; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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