Document Detail

Effects of combined interferon alpha and ribavirin therapy on thyroid functions in patients with chronic hepatitis C.
MedLine Citation:
PMID:  19208310     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the frequency of thyroid dysfunction in patients of chronic hepatitis C during treatment with interferon alpha-2b and ribavirin therapy. STUDY DESIGN: A cohort study. PLACE AND DURATION OF STUDY: Army Medical College and Military Hospital, Rawalpindi, from February 2006 to January 2007. METHODOLOGY: One hundred and sixty seven non-cirrhotic chronic hepatitis C patients were grouped into treatment group (n=107) and control group (n=60) awaiting treatment. Baseline serum(s.) Alanine Transferase (ALT) and S. Aspartate Transferase (AST) were measured by IFCC method. Serum Thyroid Stimulating Hormone (S. TSH), serum free thyroxine (S. Free T4) and serum total triiodothyronine (S.T3) level were determined by chemiluminescence. Study group patients underwent 24 weeks IFN and ribavirin therapy and were followed-up for thyroid dysfunction at weeks 0, 12 and 24. Control group patients underwent the same tests at weeks 0, 12 and 24. Statistical analysis was done on SPSS 15. RESULTS: Out of 107 patients of treatment group, 20 patients (18.69%) developed thyroid dysfunction. Females were at higher risk with Relative Risk (RR) of 11.25 and Attributable Risk (AR) of 91%. Hypothyroidism was more common than hyperthyroidism. CONCLUSION: Interferon-alpha and ribavirin therapy induces thyroid dysfunction in chronic hepatitis C patients. Hypothyroidism was more common. Females are at a higher risk of developing thyroid dysfunction.
Amina Nadeem; Muhammad Aslam; Dilshad Ahmad Khan; Tassawar Hussain; Saadat Ali Khan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  19     ISSN:  1022-386X     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  IM    
Department of Physiology, Army Medical College, Rawalpindi.
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MeSH Terms
Antiviral Agents / administration & dosage,  adverse effects*,  therapeutic use
Case-Control Studies
Cohort Studies
Drug Administration Schedule
Drug Therapy, Combination
Hepatitis C, Chronic / drug therapy*,  immunology,  virology
Interferon Alfa-2b / administration & dosage,  adverse effects*,  therapeutic use
Middle Aged
Ribavirin / administration & dosage,  adverse effects*,  therapeutic use
Thyroid Diseases / chemically induced*,  immunology
Thyroid Function Tests
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Antiviral Agents; 36791-04-5/Ribavirin; 99210-65-8/Interferon Alfa-2b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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