Document Detail


Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa.
MedLine Citation:
PMID:  19175830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM: In Japan, peptic ulcer disease (PUD) is treated clinically with a combination of a mucosal protectant and acid suppressants, but there is scant information regarding the effects of these drugs on normal gastric mucus cells. In the present study, the effects of co-administration of methylmethionine sulfonium chloride (MMSC) and famotidine on rat gastric mucus cells were investigated using both biochemical and histological methods. METHODS: Rats were divided into four groups: controls were given carboxymethylcellulose orally once daily for 7 days and the second, third and fourth groups were treated similarly with famotidine (famotidine group), MMSC (MMSC group) or famotidine plus MMSC (combination group). After killing the rats on the 8th day, the stomachs were removed and the biosynthesis and amount of mucin in different areas of the gastric mucosa were compared among groups. Using anti-mucin monoclonal antibodies, the mucin content and immunoreactivity were also compared. RESULTS: Both the biosynthesis and accumulation of mucin were significantly decreased in the famotidine group, but increased in the MMSC and combination groups. The amount and immunoreactivity of surface mucus cell-derived mucin were both reduced in the famotidine group, and increased in the MMSC and combination groups. There was no difference among the groups in the content and immunoreactivity of gland mucus cell-derived mucin. CONCLUSION: Famotidine-induced suppression of gastric surface mucus cell function is prevented by combined treatment with MMSC, raising the possibility of a more effective cure of PUD.
Authors:
Takafumi Ichikawa; Yuko Ito; Yoichi Saegusa; Tomohisa Iwai; Yukinobu Goso; Tomoaki Ikezawa; Kazuhiko Ishihara
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-03
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  24     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  488-92     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Kitasto University School of Medcine, Sagamihara, Kanagawa, Japan. t.ichika@kitasato-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anti-Ulcer Agents / administration & dosage,  pharmacology*,  toxicity
Drug Administration Schedule
Drug Therapy, Combination
Famotidine / administration & dosage,  pharmacology*,  toxicity
Gastric Mucins / biosynthesis*
Gastric Mucosa / drug effects*,  metabolism,  pathology
Histamine H2 Antagonists / administration & dosage,  pharmacology*,  toxicity
Male
Rats
Rats, Wistar
Vitamin U / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Gastric Mucins; 0/Histamine H2 Antagonists; 1115-84-0/Vitamin U; 76824-35-6/Famotidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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