Document Detail


Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats.
MedLine Citation:
PMID:  15215655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of orally administered dipeptidyl peptidase IV (DPP-IV) inhibitor on the glucose-lowering effect of glibenclamide are still unknown. We evaluated the effects of combination treatment with a long-lasting DPP-IV inhibitor, K579 ((S)-1-[4-methyl-1-(2-pyrimidinyl)-4-piperidylamino]acetyl-2-pyrrolidinecarbonitrile), and glibenclamide on the glycemic responses to glucose loading in rats. Treatment with K579 inhibited the plasma DPP-IV activity even 8 h after the administration. K579 significantly suppressed the blood glucose elevation in glibenclamide-pretreated rats without excessive hypoglycemia. These profiles of K579 indicate that it could be useful agent to correct the postprandial glucose excursion in type 2 diabetes patients by combination treatment with glibenclamide.
Authors:
Kotaro Takasaki; Takao Nakajima; Kimihisa Ueno; Yuji Nomoto; Katsuya Higo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  95     ISSN:  1347-8613     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2005-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  291-3     Citation Subset:  IM    
Affiliation:
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan. kotaro.takasaki@kyowa.co.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD26 / metabolism*
Blood Glucose / metabolism*
Glyburide / pharmacology
Hypoglycemic Agents / pharmacology*
Male
Protease Inhibitors / pharmacology*
Rats
Rats, Wistar
Sulfonylurea Compounds / pharmacology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 0/Protease Inhibitors; 0/Sulfonylurea Compounds; 10238-21-8/Glyburide; EC 3.4.14.5/Antigens, CD26

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