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Effects of combination of fluticasone propionate and salmeterol xinafoate on lung function improvement in patients with bronchiectasis.
MedLine Citation:
PMID:  22046624     Owner:  NLM     Status:  In-Process    
INTRODUCTION: Bronchiectasis is defined as bronchial abnormal and permanent dilation with destructive and inflammatory changes of bronchial wall. Bronchodilators are used to treat the disease in order to improve lung functions. Seretide is the combination of fluticasone propionate and salmeterol xinafoate (FLU/SAL). The effect of each has been proved in the improvement of bronchiectasis, while their synthetic effect as FLU/SAL on bronchiectasis improvement has not been studied yet.
AIM: The aim of this study was to investigate the effects of FLU/SAL on the lung function improvement in bronchiectasis patients, comparing and interpreting pulmonary function tests before and after FLU/SAL inhalation.
METHODS AND MATERIALS: Twelve patients with bronchiectasis who referred to Rasoul-e-Akram Hospital, Tehran, Iran in 2008 participated in this prospective quasi-experimental trial. The patients were treated with 2 puffs of fluticasone 125 μg and salmeterol 50 μg (Seretide) twice a day for one month. Beside recording demographic variables, the results of pulmonary function tests (PFT) including vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in the first second (FEV₁) and FEV₁/FVC ratio were recorded before and after the treatment. Data were analyzed using SPSS v.16 and Pearson correlation and paired T-test were performed.
RESULTS: Among 12 patients with bronchiectasis, there were 4 men and 8 women with the mean age of 47.58 (SD=18.32) yr. The mean increase in the ratios of VC, FVC and FEV₁ to predicted values and also patients FEV₁/FVC after treatment were 15.50% (SD=14.40), 49.83% (SD=8.19) 8.17% (SD=12.07) and 7.17% (SD=12.68), respectively. The results of paired T-test indicated that VC (P=0.008) and FEV₁(P=0.039) have increased significantly after treatment.
CONCLUSION: This study is one of the first studies investigating the FLU/SAL effect on bronchiectasis. Results of this study have indicated that using FLU/SAL has a significant effect on the improvement of lung function parameters in these patients, while the attention was been focused on antibiotic therapy or other bronchodilators.
Elyas Mostafapour; Seyed-Ali Javad Mousavi; Shahab Shahabi Shahmiri; Seyed-Mohammad Fereshtehnejad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lijec̆nic̆ki vjesnik     Volume:  131 Suppl 6     ISSN:  0024-3477     ISO Abbreviation:  Lijec Vjesn     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2011-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0074253     Medline TA:  Lijec Vjesn     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  8-11     Citation Subset:  IM    
Iran University of Medical Sciences and Health Servics, Tehran, Iran.
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