Document Detail

Effects of a combination of atropine, metaraminol and pyridine aldoxime methanesulfonate (AMP therapy) on normal human subjects.
MedLine Citation:
PMID:  5318965     Owner:  NLM     Status:  MEDLINE    
Four hundred and seventeen medical students at the University of Toronto were used as both subjects and observers in a series of double-blind experiments to determine possible toxic effects following oral ingestion of various combinations of 2 mg. atropine, 10 mg. metaraminol and 1 g. pyridine aldoxime methanesulfonate (P(2)S). Heart rate, blood pressure, pupil diameter, and visual accommodation were measured before and at 20-minute intervals after drug administration for 100 minutes. A visual and memory perceptual test (Mackworth) was performed before and 100 minutes after drug ingestion.No toxic effects were observed following administration of the triple combination of atropine, metaraminol and P(2)S (AMP therapy). The AMP combination might be useful prophylactically for persons facing exposure to organophosphorus anticholinesterase compounds. It must not be considered an adequate substitute for treatment should poisoning occur.
W J Taylor; E Llewellyn-Thomas; E A Sellers; G C Walker
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  93     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1965 Oct 
Date Detail:
Created Date:  1965-12-08     Completed Date:  1965-12-08     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  957-61     Citation Subset:  AIM; IM    
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MeSH Terms
Atropine / toxicity*
Blood Pressure / drug effects
Cholinesterase Inhibitors / poisoning
Clinical Trials as Topic
Heart Rate / drug effects
Insecticides / poisoning
Metaraminol / toxicity*
Pralidoxime Compounds / toxicity*
Psychological Tests
Pulse / drug effects
Pupil / drug effects
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Insecticides; 0/Pralidoxime Compounds; 51-55-8/Atropine; 54-49-9/Metaraminol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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