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Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study.
MedLine Citation:
PMID:  22371793     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: An increase in oxidative stress is strongly documented in hypertensive patients. In blood vessels, oxidative stress increases the production of superoxide anion (O(2) (•-)) that reacts with nitric oxide (NO) and impairs the ability of endothelium to relax. Many reports indicate a beneficial effect of coenzyme Q10 (CoQ) in hypertension. Coenzyme Q10 therapy may lower O(2) (•-) and thus decrease the complications associated with hypertension. The aim of our study was to evaluate the effects of CoQ supplementation on antioxidative enzyme activities and lipid peroxidation in elderly hypertensive patients.
MATERIAL AND METHODS: We determined the activities of superoxide dismutase (SOD-1) and glutathione peroxidase (GSH-Px) and the concentration of malondialdehyde (MDA) in erythrocytes of 27 elderly (mean age 72.5 ±6.1 year) hypertensive patients treated with indapamide at baseline and after 12 weeks of CoQ supplementation (60 mg twice a day) in comparison with 30 healthy elderly volunteers (mean age 76.8 ±8.5 year).
RESULTS: Decrease of SOD-1 (p < 0.001) and insignificant reduction of GSH-Px activities and increase of MDA (p < 0.001) level were observed in hypertensive patients in comparison to healthy volunteers before supplementation. Coenzyme Q10 administration resulted in a significant increase only in SOD-1 activity (p < 0.001).
CONCLUSIONS: The present study indicates that CoQ improves the most important component of the antioxidant defence system - SOD-1, which is responsible for O(2) (•-) scavenging. Coenzyme Q10 may be used as an additional therapeutic agent for prophylaxis and treatment of hypertension in elderly patients.
Kornelia Kędziora-Kornatowska; Jolanta Czuczejko; Jadwiga Motyl; Karolina Szewczyk-Golec; Mariusz Kozakiewicz; Hanna Pawluk; Józef Kędziora; Robert Błaszczak; Maciej Banach; Jacek Rysz
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Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Archives of medical science : AMS     Volume:  6     ISSN:  1896-9151     ISO Abbreviation:  Arch Med Sci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101258257     Medline TA:  Arch Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  -    
Department and Clinic of Geriatrics, Nicolaus Copernicus University Collegium Medicum , Bydgoszcz, Poland.
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