| Effects of cocaine and ethanol on mouse fetuses. | |
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MedLine Citation:
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PMID: 11556395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the presence of ethanol, cocaine is metabolized to its ethyl homolog, cocaethylene. To investigate the embryotoxic effects of cocaethylene, pregnant ICR mice receiving ethanol orally during pregnancy were treated with 50 mg/kg/day cocaine i.p. on days 7, 8 and 9 of gestation. Treatment with either cocaine or ethanol alone did not affect the fetal mortality rate or the mean fetal body weight. Concurrent cocaine and ethanol treatment increased the fetal mortality rate, and decreased the mean fetal body weight, although teratogenicity was not noted. These results suggest that concurrent use of cocaine and ethanol during pregnancy is more harmful to fetal body weight gain and their lives than the use of either drug alone, at least in the present experimental settings. |
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Authors:
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H Ohnaka; K Ukita; S Yamamasu; M Inoue; M Imanaka; O Ishiko; S Ogita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Osaka city medical journal Volume: 47 ISSN: 0030-6096 ISO Abbreviation: Osaka City Med J Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-09-14 Completed Date: 2001-09-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376413 Medline TA: Osaka City Med J Country: Japan |
Other Details:
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Languages: eng Pagination: 83-93 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Cocaine / pharmacology* Drug Synergism Ethanol / pharmacology* Fetal Death / epidemiology Fetus / drug effects* Incidence Mice Mice, Inbred ICR |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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