Document Detail


Effects of cocaine and ethanol on mouse fetuses.
MedLine Citation:
PMID:  11556395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the presence of ethanol, cocaine is metabolized to its ethyl homolog, cocaethylene. To investigate the embryotoxic effects of cocaethylene, pregnant ICR mice receiving ethanol orally during pregnancy were treated with 50 mg/kg/day cocaine i.p. on days 7, 8 and 9 of gestation. Treatment with either cocaine or ethanol alone did not affect the fetal mortality rate or the mean fetal body weight. Concurrent cocaine and ethanol treatment increased the fetal mortality rate, and decreased the mean fetal body weight, although teratogenicity was not noted. These results suggest that concurrent use of cocaine and ethanol during pregnancy is more harmful to fetal body weight gain and their lives than the use of either drug alone, at least in the present experimental settings.
Authors:
H Ohnaka; K Ukita; S Yamamasu; M Inoue; M Imanaka; O Ishiko; S Ogita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Osaka city medical journal     Volume:  47     ISSN:  0030-6096     ISO Abbreviation:  Osaka City Med J     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-09-14     Completed Date:  2001-09-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376413     Medline TA:  Osaka City Med J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Cocaine / pharmacology*
Drug Synergism
Ethanol / pharmacology*
Fetal Death / epidemiology
Fetus / drug effects*
Incidence
Mice
Mice, Inbred ICR
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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