| Effects of cocaine on blood flow and oxygen metabolism in the rat brain: implications for phMRI. | |
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MedLine Citation:
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PMID: 17442519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of cocaine on cerebral blood flow and tissue oxygen levels in the rat brain were investigated with concurrent laser Doppler flowmetry and fluorescence quenching spectroscopy. Responses elicited by mild hypercapnia were used as calibration to assess the effects of cocaine on oxidative metabolism. Intravenous cocaine challenge of 0.5 mg/kg induced significant increases in tissular oxygenation and perfusion in all regions investigated (primary motor cortex, medial prefrontal cortex and dorsal striatum). Mild hypercapnia, a challenge that affects haemodynamics but not metabolism, elicited comparable changes in blood flow but substantially larger changes in tissue oxygen levels. These differences in tissue oxygen build-up suggest that increased oxidative metabolism is a significant component of the cerebral metabolic response to acute cocaine challenge. The implications for the interpretation of pharmacological MRI data are discussed. |
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Authors:
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Laura Ceolin; Adam J Schwarz; Alessandro Gozzi; Torsten Reese; Angelo Bifone |
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Publication Detail:
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Type: Journal Article Date: 2007-04-18 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 25 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-27 Completed Date: 2007-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 795-800 Citation Subset: IM |
Affiliation:
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Department of Neuroimaging, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre, 37135 Verona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects* Brain / metabolism* Cocaine / pharmacology* Dopamine Uptake Inhibitors / pharmacology Equipment Design Hypercapnia / pathology Magnetic Resonance Imaging / methods* Male Models, Biological Oxygen / metabolism* Oxygen Consumption Prefrontal Cortex / pathology Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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