| Effects of co-administration of antidepressants and monoamine oxidase inhibitors on 5-HT-related behavior in rats. | |
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MedLine Citation:
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PMID: 17400208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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5-hydroxytryptamine (5-HT) syndrome is a dangerous condition of 5-HT excess that can occur during co-administration of a monoamine oxidase (MAO) inhibitor and an antidepressant. We investigated the effects of acute administration of MAO inhibitors and subchronic administration of tricyclic and heterocyclic antidepressants, and a serotonin-noradrenaline reuptake inhibitor (SNRI) on 5-HT syndrome in rats treated with 5-hydroxytryptophan (5-HTP). The irreversible and non-selective MAO inhibitor pargyline, and the reversible and selective MAO-A inhibitor clorgyline, produced increases in 5-HT syndrome in the 5-HTP-treated rats, while subchronic co-administration of imipramine partly intensified and partly attenuated the syndrome, whereas milnacipran only attenuated the syndrome. Co-administration of mianserin partly intensified and partly attenuated the syndrome but the attenuating effect was dominant. Administration of the irreversible and selective MAO-B inhibitor selegiline did not produce any increase in 5-HT syndrome in the 5-HTP-treated rats, compared with the saline control. These data suggest that non-selective MAO and selective MAO-A inhibitors can induce 5-HT syndrome in humans when co-administered with antidepressants. Furthermore, the risk of 5-HT syndrome may be lower with the selective MAO-B inhibitor selegiline. |
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Authors:
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Takeshi Izumi; Nobuyuki Iwamoto; Yuji Kitaichi; Akiko Kato; Takeshi Inoue; Tsukasa Koyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-12 |
Journal Detail:
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Title: European journal of pharmacology Volume: 565 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-28 Completed Date: 2007-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 105-12 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060-8638, Japan. psyizumi@med.hokudai.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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5-Hydroxytryptophan
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pharmacology Animals Antidepressive Agents / pharmacology* Cyclopropanes / pharmacology Drug Interactions Imipramine / pharmacology Male Mianserin / pharmacology Monoamine Oxidase Inhibitors / pharmacology* Rats Rats, Sprague-Dawley Serotonin / secretion* Serotonin Syndrome / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Cyclopropanes; 0/Monoamine Oxidase Inhibitors; 24219-97-4/Mianserin; 50-49-7/Imipramine; 50-67-9/Serotonin; 56-69-9/5-Hydroxytryptophan; 92623-85-3/milnacipran |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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